Basic information
Locus name	AT1G64280
Alias	NPR1/SAI1/NIM1
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Hormone response pathway:SA
Effect for Senescence	promote
Gene Description	a key regulator of the salicylic acid (SA)-mediated systemic acquired resistance (SAR) pathway.
Evidence	Genetic evidence:Mutant [Ref 1]
References	1: Morris K, MacKerness SA, Page T, John CF, Murphy AM, Carr JP, Buchanan-Wollaston V Salicylic acid has a role in regulating gene expression during leaf senescence. Plant J. 2000 Sep;23(5):677-85
Gene Ontology	molecular function protein binding
Sequence	AT1G64280.1 | Genomic | mRNA | CDS | Protein
Mutant information
Mutant name	npr1-1
Mutant/Transgenic	mutant
Ecotype	Col-0
Mutagenesis type	EMS
miRNA Interaction
Details	target: AT1G64280.1  miRNA: ath-miR780 miRNA: ath-miR780 mfe: -28.0 kcal/mol  p-value: 0.029297  position:  1685  target 5' C  G                C  C 3'             GC CUGUUCGGCAGU GCU GA              UG GACGAGUUGUCG CGA CU   miRNA  3'                 A   U    5'  target: AT1G64280.1  miRNA: ath-miR843 miRNA: ath-miR843 mfe: -28.5 kcal/mol  p-value: 0.014944  position:  484  target 5' G              G      G 3'             CC GUGAAGCUCGA CUUAAG              GG UACUUCGAGCU GGAUUU   miRNA  3' A  U                    5'
Ortholog Group
Ortholog Groups: OG5_177607	Accession Taxon NP_176610 ( AT1G64280 ) Arabidopsis thaliana NP_194342 Arabidopsis thaliana NP_001042286 Oryza sativa Japonica Group 29912.m005368 Ricinus communis
Cross Link
Database Entry ID E-value Start End InterPro ID Description SUPERFAMILY SSF54695 2.0E-9 61 192 IPR011333 BTB/POZ fold Pfam PF00651 6.1E-9 63 190 IPR013069 BTB/POZ ProSiteProfiles PS50097 15.6 65 144 IPR000210 BTB/POZ-like SMART SM00225 2.3E-15 65 194 IPR000210 BTB/POZ-like SMART SM00248 210.0 265 295 IPR002110 Ankyrin repeat SUPERFAMILY SSF48403 2.5E-18 266 371 IPR020683 Ankyrin repeat-containing domain Pfam PF12796 2.2E-11 271 355 IPR020683 Ankyrin repeat-containing domain ProSiteProfiles PS50297 17.7 294 369 IPR020683 Ankyrin repeat-containing domain ProSiteProfiles PS50088 9.8 328 360 IPR002110 Ankyrin repeat SMART SM00248 1.9 328 357 IPR002110 Ankyrin repeat Pfam PF12313 2.1E-81 370 575 IPR021094 NPR1/NIM1-like, C-terminal Coils Coil NA 419 440 No hit NA
Mutant Image
npr1 mutant exhibited delay senescence
Subcellular Localization
Localization 1 Localization nucleus Evidence Localization with GFP-fusion protein (GFP:cDNA) Pubmed ID 10737809
Localization 2 Localization nucleus Evidence SUBAcon Pubmed ID 23180787