Basic information
Locus name	AT2G01830
Alias	CRE1/AHK4
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Hormone response pathway:CK
Effect for Senescence	delay
Gene Description	Histidine kinase: cytokinin-binding receptor that transduces cytokinin signals across the plasma membrane.
Evidence	Genetic evidence:Mutant [Ref 1]
References	1: Riefler M, Novak O, Strnad M, Schmulling T Arabidopsis cytokinin receptor mutants reveal functions in shoot growth, leaf senescence, seed size, germination, root development, and cytokinin metabolism. Plant Cell 2006 Jan;18(1):40-54
Gene Ontology	biological process phosphorelay signal transduction system phosphorylation regulation of transcription, DNA-dependent signal transduction molecular function phosphorelay response regulator activity phosphorelay sensor kinase activity transferase activity, transferring phosphorus-containing groups
Pathway	Reactome REACT_14797 REACT_1046
Sequence	AT2G01830.1 | Genomic | mRNA | CDS | Protein AT2G01830.2 | Genomic | mRNA | CDS | Protein AT2G01830.3 | Genomic | mRNA | CDS | Protein
Mutant information
Mutated 1 Mutant name ahk2ahk3cre1 Mutant/Transgenic mutant Ecotype Col-0 Mutagenesis type T-DNA insertion_knock out
Mutated 2 Mutant name ahk3cre1 Mutant/Transgenic mutant Ecotype Col-0 Mutagenesis type T-DNA insertion_knock out
Mutated 3 Mutant name cre1/ahk4 Mutant/Transgenic mutant Ecotype Col-0 Mutagenesis type T-DNA insertion_knock out
Ortholog Group
Ortholog Groups: OG5_129304	Accession Taxon NP_564276 Arabidopsis thaliana NP_565277 Arabidopsis thaliana NP_568532 Arabidopsis thaliana NP_849925 ( AT2G01830 ) Arabidopsis thaliana NP_973396 Arabidopsis thaliana 114537 Chlamydomonas reinhardtii 97170 Chlamydomonas reinhardtii NP_001045241 Oryza sativa Japonica Group NP_001048061 Oryza sativa Japonica Group NP_001064436 Oryza sativa Japonica Group gw1.09.00.217.1 Ostreococcus tauri e_gw1.194.71.1 Physcomitrella patens subsp. patens estExt_fgenesh1_pg.C_1440014 Physcomitrella patens subsp. patens estExt_gwp_gw1.C_2710020 Physcomitrella patens subsp. patens estExt_gwp_gw1.C_500074 Physcomitrella patens subsp. patens fgenesh1_pg.scaffold_252000025 Physcomitrella patens subsp. patens fgenesh1_pg.scaffold_44000141 Physcomitrella patens subsp. patens 29597.m000294 Ricinus communis 29929.m004637 Ricinus communis 29968.m000653 Ricinus communis XP_002954901 Volvox carteri f. nagariensis
Cross Link
Database Entry ID E-value Start End InterPro ID Description PANTHER PTHR24423 2.7E-130 28 1078 No hit NA ProSiteProfiles PS50839 44.2 198 411 IPR006189 CHASE SMART SM01079 9.0E-33 198 384 IPR006189 CHASE Pfam PF03924 2.6E-40 199 384 IPR006189 CHASE SUPERFAMILY SSF47384 3.3E-18 458 538 IPR009082 Signal transduction histidine kinase, homodimeric domain Pfam PF00512 1.0E-18 472 537 IPR003661 Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain SMART SM00388 2.7E-23 472 537 IPR003661 Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain ProSiteProfiles PS50109 40.8 479 760 IPR005467 Signal transduction histidine kinase, core Coils Coil NA 522 543 No hit NA SUPERFAMILY SSF55874 3.0E-38 526 618 IPR003594 Histidine kinase-like ATPase, ATP-binding domain Pfam PF02518 3.5E-35 584 758 IPR003594 Histidine kinase-like ATPase, ATP-binding domain SMART SM00387 2.5E-31 584 760 IPR003594 Histidine kinase-like ATPase, ATP-binding domain SUPERFAMILY SSF55874 3.0E-38 684 755 IPR003594 Histidine kinase-like ATPase, ATP-binding domain PRINTS PR00344 2.0E-10 685 699 IPR004358 Signal transduction histidine kinase-related protein, C-terminal PRINTS PR00344 2.0E-10 703 713 IPR004358 Signal transduction histidine kinase-related protein, C-terminal PRINTS PR00344 2.0E-10 720 738 IPR004358 Signal transduction histidine kinase-related protein, C-terminal SUPERFAMILY SSF52172 5.0E-5 781 922 IPR011006 CheY-like superfamily SUPERFAMILY SSF52172 1.6E-33 943 1069 IPR011006 CheY-like superfamily SMART SM00448 1.0E-31 945 1067 IPR001789 Signal transduction response regulator, receiver domain ProSiteProfiles PS50110 30.0 946 1071 IPR001789 Signal transduction response regulator, receiver domain Pfam PF00072 1.4E-21 947 1067 IPR001789 Signal transduction response regulator, receiver domain
Mutant Image
ahk3cre1 mutants exhibited early senescence phenotype compared with wild type.
Subcellular Localization
Localization 1 Localization cytosol Evidence SUBAcon Pubmed ID 23180787
Localization 2 Localization endoplasmic reticulum Evidence SUBAcon Pubmed ID 23180787