Basic information
Locus name	AT1G15750
Alias	TPL
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Transcription regulation
Effect for Senescence	unclear
Gene Description	TOPLESS (TPL); FUNCTIONS IN: protein binding, transcription repressor activity, protein homodimerization activity
Evidence	Genomic evidence:microarray data [Ref 1]
References	1: Breeze E, Harrison E, McHattie S, Hughes L, Hickman R, Hill C, Kiddle S, Kim YS, Penfold CA, Jenkins D, Zhang C, Morris K, Jenner C, Jackson S, Thomas B, Tabrett A, Legaie R, Moore JD, Wild DL, Ott S, Rand D, Beynon J, Denby K, Mead A, Buchanan-Wollaston High-resolution temporal profiling of transcripts during Arabidopsis leaf senescence reveals a distinct chronology of processes and regulation. Plant Cell 2011 Mar;23(3):873-94
Gene Ontology	molecular function protein binding
Sequence	AT1G15750.1 | Genomic | mRNA | CDS | Protein AT1G15750.2 | Genomic | mRNA | CDS | Protein AT1G15750.3 | Genomic | mRNA | CDS | Protein AT1G15750.4 | Genomic | mRNA | CDS | Protein
Ortholog Group
Ortholog Groups: OG5_136634	Accession Taxon NP_001031050 Arabidopsis thaliana NP_001031051 ( AT1G15750 ) Arabidopsis thaliana NP_178164 Arabidopsis thaliana NP_188209 Arabidopsis thaliana NP_188306 Arabidopsis thaliana NP_198055 Arabidopsis thaliana NP_563981 Arabidopsis thaliana NP_849672 Arabidopsis thaliana NP_849913 Arabidopsis thaliana NP_851003 Arabidopsis thaliana NP_001042616 Oryza sativa Japonica Group NP_001049587 Oryza sativa Japonica Group NP_001061055 Oryza sativa Japonica Group e_gw1.316.3.1 Physcomitrella patens subsp. patens estExt_fgenesh2_pm.C_990019 Physcomitrella patens subsp. patens 29841.m002924 Ricinus communis 29848.m004586 Ricinus communis 29848.m004589 Ricinus communis 29927.m000603 Ricinus communis 30073.m002232 Ricinus communis 30128.m008872 Ricinus communis
Cross Link
Database Entry ID E-value Start End InterPro ID Description ProSiteProfiles PS50896 10.3 4 36 IPR006594 LisH dimerisation motif SMART SM00667 3.1E-5 4 36 IPR006594 LisH dimerisation motif ProSiteProfiles PS50897 14.3 34 92 IPR006595 CTLH, C-terminal LisH motif SMART SM00668 5.5E-16 34 92 IPR006595 CTLH, C-terminal LisH motif PANTHER PTHR22847 0.0 95 1114 No hit NA SMART SM00320 63.0 345 384 IPR001680 WD40 repeat SUPERFAMILY SSF50978 9.2E-7 350 447 IPR017986 WD40-repeat-containing domain SMART SM00320 57.0 406 445 IPR001680 WD40 repeat ProSiteProfiles PS50294 18.8 413 634 IPR017986 WD40-repeat-containing domain SUPERFAMILY SSF50978 1.8E-38 419 699 IPR017986 WD40-repeat-containing domain SMART SM00320 2.6E-5 451 492 IPR001680 WD40 repeat Pfam PF00400 1.6E-6 458 492 IPR001680 WD40 repeat ProSiteProfiles PS50082 10.6 458 501 IPR001680 WD40 repeat ProSitePatterns PS00678 NA 479 493 IPR019775 WD40 repeat, conserved site SMART SM00320 0.0 495 536 IPR001680 WD40 repeat Pfam PF00400 7.8E-4 499 535 IPR001680 WD40 repeat SMART SM00320 25.0 539 582 IPR001680 WD40 repeat SMART SM00320 0.9 585 625 IPR001680 WD40 repeat ProSiteProfiles PS50082 9.3 593 634 IPR001680 WD40 repeat SMART SM00320 76.0 825 862 IPR001680 WD40 repeat ProSiteProfiles PS50294 14.7 831 956 IPR017986 WD40-repeat-containing domain SUPERFAMILY SSF50978 3.9E-36 832 1094 IPR017986 WD40-repeat-containing domain SMART SM00320 1.3 865 905 IPR001680 WD40 repeat SMART SM00320 2.9E-5 908 947 IPR001680 WD40 repeat Pfam PF00400 2.4E-5 910 947 IPR001680 WD40 repeat ProSiteProfiles PS50082 12.1 915 956 IPR001680 WD40 repeat ProSitePatterns PS00678 NA 934 948 IPR019775 WD40 repeat, conserved site SMART SM00320 5.1 999 1040 IPR001680 WD40 repeat SMART SM00320 61.0 1053 1093 IPR001680 WD40 repeat
Subcellular Localization
Localization	cytosol
Evidence	SUBAcon
Pubmed ID	23180787