Basic information
Locus name	AT4G23750
Alias	CRF2
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Transcription regulation:ERF
Effect for Senescence	promote
Gene Description	_cytokinin response factors (CRFs) are a group of related AP2/ERF transcription factors that are transcriptionally induced by cytokinin._
Evidence	Genetic evidence [Ref 1]
References	1: Raines T, Shanks C, Cheng CY, McPherson D, Argueso CT, Kim HJ, Franco-Zorrilla JM, López-Vidriero I, Solano R, Va_ková R, Schaller GE, Kieber JJ. The cytokinin response factors modulate root and shoot growth and promote leaf senescence in Arabidopsis. Plant J. 2016 Jan;85(1):134-47. doi: 10.1111/tpj.13097.
Gene Ontology	biological process regulation of transcription, DNA-dependent molecular function sequence-specific DNA binding transcription factor activity
Sequence	AT4G23750.1 | Genomic | mRNA | CDS | Protein AT4G23750.2 | Genomic | mRNA | CDS | Protein
Mutant information
Mutant name	crf2-3 (SAIL_371_D04),crf1,3,5,6
Mutant/Transgenic	mutant
Ecotype	Col-0
Mutagenesis type	T-DNA
Ortholog Group
Ortholog Groups: OG5_137078	Accession Taxon NP_182154 Arabidopsis thaliana NP_182274 Arabidopsis thaliana NP_191722 Arabidopsis thaliana NP_192852 Arabidopsis thaliana NP_194106 Arabidopsis thaliana NP_974599 ( AT4G23750 ) Arabidopsis thaliana ACO66484 Micromonas sp. RCC299 NP_001042450 Oryza sativa Japonica Group NP_001043760 Oryza sativa Japonica Group estExt_fgenesh1_pg.C_Chr_04.00010339 Ostreococcus tauri e_gw1.21.268.1 Physcomitrella patens subsp. patens e_gw1.7.264.1 Physcomitrella patens subsp. patens estExt_fgenesh1_pg.C_1260014 Physcomitrella patens subsp. patens estExt_fgenesh1_pg.C_210126 Physcomitrella patens subsp. patens gw1.126.81.1 Physcomitrella patens subsp. patens gw1.293.27.1 Physcomitrella patens subsp. patens gw1.293.28.1 Physcomitrella patens subsp. patens gw1.7.214.1 Physcomitrella patens subsp. patens 28049.m000300 Ricinus communis 30190.m010791 Ricinus communis
Cross Link
Database Entry ID E-value Start End InterPro ID Description Pfam PF00847 7.9E-16 120 170 IPR001471 AP2/ERF domain ProSiteProfiles PS51032 23.4 121 178 IPR001471 AP2/ERF domain SMART SM00380 2.1E-37 121 184 IPR001471 AP2/ERF domain SUPERFAMILY SSF54171 1.1E-21 121 179 IPR016177 DNA-binding, integrase-type PANTHER PTHR31190 1.8E-24 122 189 No hit NA PRINTS PR00367 7.7E-10 122 133 IPR001471 AP2/ERF domain PRINTS PR00367 7.7E-10 144 160 IPR001471 AP2/ERF domain
Mutant Image
crf1,3,5,6 and crf1/CRF1,2,5,6 lines showed delayed senescence; CRF1OX, CRF3OX, CRF5OX lines displayed early leaf senescence
Subcellular Localization
Localization	nucleus
Evidence	SUBAcon
Pubmed ID	23180787