Basic information
Locus name	AT1G70140
Alias	ATFH8
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Others(actin binding)
Effect for Senescence	unclear
Gene Description	formin 8 (ATFH8); FUNCTIONS IN: actin binding, actin filament binding, profilin binding; INVOLVED IN: actin nucleation, cell tip growth
Evidence	Genomic evidence:microarray data [Ref 1]
References	1: Breeze E, Harrison E, McHattie S, Hughes L, Hickman R, Hill C, Kiddle S, Kim YS, Penfold CA, Jenkins D, Zhang C, Morris K, Jenner C, Jackson S, Thomas B, Tabrett A, Legaie R, Moore JD, Wild DL, Ott S, Rand D, Beynon J, Denby K, Mead A, Buchanan-Wollaston High-resolution temporal profiling of transcripts during Arabidopsis leaf senescence reveals a distinct chronology of processes and regulation. Plant Cell 2011 Mar;23(3):873-94
Gene Ontology	biological process actin cytoskeleton organization cellular component organization molecular function actin binding
Sequence	AT1G70140.1 | Genomic | mRNA | CDS | Protein
Microarray
Sampling	Buchanan-Wollaston V, Page T, Harrison E, Breeze E, Lim PO, Nam HG, Lin JF, Wu SH, Swidzinski J, Ishizaki K, Leaver CJ. Comparative transcriptome analysis reveals significant differences in gene expression and signalling pathways between developmental and dark/starvation-induced senescence in Arabidopsis. Plant J. 2005 May;42(4)
Comparation	Legends: Col: wild type, indicates the ratio of expression in senescing leaves/green leaves. NahG, coi1 and ein2: indicates the ratio of expression in senescing leaves of mutant/senescing wild type. CD: Cell Death, ratio of starved cell suspension culture/control. Genes showing at least 3 fold (ratio) up regulation during leaf senescence.
Ortholog Group
Ortholog Groups: OG5_177539	Accession Taxon NP_173825 Arabidopsis thaliana NP_177171 ( AT1G70140 ) Arabidopsis thaliana NP_001048066 Oryza sativa Japonica Group 29736.m002101 Ricinus communis
Cross Link
Database Entry ID E-value Start End InterPro ID Description PANTHER PTHR23213 6.6E-142 8 722 No hit NA PRINTS PR01217 7.2E-9 50 62 No hit NA PRINTS PR01217 7.2E-9 114 126 No hit NA PRINTS PR01217 7.2E-9 226 243 No hit NA SUPERFAMILY SSF101447 3.1E-85 238 243 IPR015425 Actin-binding FH2 PRINTS PR01217 7.2E-9 252 277 No hit NA ProSiteProfiles PS51444 45.6 296 732 IPR015425 Actin-binding FH2 SMART SM00498 3.1E-151 296 721 IPR003104 Actin-binding FH2/DRF autoregulatory Pfam PF02181 1.8E-118 299 707 IPR015425 Actin-binding FH2 SUPERFAMILY SSF101447 3.1E-85 309 549 IPR015425 Actin-binding FH2 SUPERFAMILY SSF101447 3.1E-85 595 721 IPR015425 Actin-binding FH2
Subcellular Localization
Localization	plasma membrane
Evidence	SUBAcon
Pubmed ID	23180787