Basic information
Locus name	AT3G06110
Alias	MKP2
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Protein degradation/modification
Effect for Senescence	unclear
Gene Description	MAPK PHOSPHATASE 2 (MKP2); FUNCTIONS IN: MAP kinase phosphatase activity, protein tyrosine/serine/threonine phosphatase activity; INVOLVED IN: protein kinase cascade, response to ozone, response to stress, negative regulation of MAP kinase activity
Evidence	Genomic evidence:microarray data [Ref 1]
References	1: Breeze E, Harrison E, McHattie S, Hughes L, Hickman R, Hill C, Kiddle S, Kim YS, Penfold CA, Jenkins D, Zhang C, Morris K, Jenner C, Jackson S, Thomas B, Tabrett A, Legaie R, Moore JD, Wild DL, Ott S, Rand D, Beynon J, Denby K, Mead A, Buchanan-Wollaston High-resolution temporal profiling of transcripts during Arabidopsis leaf senescence reveals a distinct chronology of processes and regulation. Plant Cell 2011 Mar;23(3):873-94
Gene Ontology	biological process protein dephosphorylation molecular function protein tyrosine/serine/threonine phosphatase activity
Sequence	AT3G06110.1 | Genomic | mRNA | CDS | Protein AT3G06110.2 | Genomic | mRNA | CDS | Protein AT3G06110.3 | Genomic | mRNA | CDS | Protein
Mutant information
Mutant name	AtMKP2i
Mutant/Transgenic	transgenic
Ecotype	Col-0
Mutagenesis type	RNAi
Ortholog Group
Ortholog Groups: OG5_128368	Accession Taxon NP_566272 Arabidopsis thaliana NP_850522 ( AT3G06110 ) Arabidopsis thaliana CMP161C Cyanidioschyzon merolae strain 10D 103158 Chlamydomonas reinhardtii 196136 Chlamydomonas reinhardtii
Cross Link
Database Entry ID E-value Start End InterPro ID Description SUPERFAMILY SSF52799 1.6E-36 23 155 No hit NA PANTHER PTHR10159 6.8E-69 24 156 IPR024950 Dual specificity phosphatase ProSiteProfiles PS50054 29.5 24 154 IPR020422 Dual specificity phosphatase, subgroup, catalytic domain SMART SM00195 1.8E-37 24 152 IPR020422 Dual specificity phosphatase, subgroup, catalytic domain Pfam PF00782 5.8E-30 32 151 IPR000340 Dual specificity phosphatase, catalytic domain ProSiteProfiles PS50056 13.5 67 133 IPR000387 Protein-tyrosine/Dual specificity phosphatase
Mutant Image
Silencing MKP2 induced early senescence.Overexpression of MKP2 did not alter senescence phenotype.
Subcellular Localization
Localization 1 Localization cytosol Evidence SUBAcon Pubmed ID 23180787
Localization 2 Localization cytosol,nucleus Evidence SUBAcon Pubmed ID 23180787