Basic information
Locus name	AT1G11680
Alias	CYP51A2
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Hormone response pathway:ET and terol biosynthesis
Effect for Senescence	delay
Gene Description	putative obtusifoliol 14-alpha demethylase involved in sterol biosynthesis
Evidence	Genetic evidence:Mutant [Ref 1]
References	1: Kim HB, Lee H, Oh CJ, Lee HY, Eum HL, Kim HS, Hong YP, Lee Y, Choe S, An CS, Choi SB Postembryonic seedling lethality in the sterol-deficient Arabidopsis cyp51A2 mutant is partially mediated by the composite action of ethylene and reactive oxygen species. Plant Physiol. 2010 Jan;152(1):192-205
Gene Ontology	biological process oxidation-reduction process molecular function electron carrier activity heme binding iron ion binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
Pathway	Reactome REACT_13433
Sequence	AT1G11680.1 | Genomic | mRNA | CDS | Protein
Mutant information
Mutant name	cyp51A2
Mutant/Transgenic	mutant
Ecotype	Col-0
Mutagenesis type	T-DNA insertion_knock out
Ortholog Group
Ortholog Groups: OG5_129288	Accession Taxon NP_172633 ( AT1G11680 ) Arabidopsis thaliana CMS319C Cyanidioschyzon merolae strain 10D 196411 Chlamydomonas reinhardtii ACO70477 Micromonas sp. RCC299 NP_001054917 Oryza sativa Japonica Group NP_001067991 Oryza sativa Japonica Group e_gw1.11.00.152.1 Ostreococcus tauri e_gw1.114.55.1 Physcomitrella patens subsp. patens 30128.m008568 Ricinus communis e_gw1.4.205.1 Thalassiosira pseudonana CCMP1335 XP_002946369 Volvox carteri f. nagariensis
Cross Link
Database Entry ID E-value Start End InterPro ID Description PANTHER PTHR24286 2.5E-127 13 486 No hit NA SUPERFAMILY SSF48264 8.3E-95 35 485 IPR001128 Cytochrome P450 PRINTS PR00465 2.8E-38 40 57 IPR002403 Cytochrome P450, E-class, group IV Pfam PF00067 5.1E-68 41 460 IPR001128 Cytochrome P450 PRINTS PR00465 2.8E-38 62 85 IPR002403 Cytochrome P450, E-class, group IV PRINTS PR00465 2.8E-38 279 305 IPR002403 Cytochrome P450, E-class, group IV PRINTS PR00385 1.3E-7 288 305 IPR001128 Cytochrome P450 PRINTS PR00465 2.8E-38 337 353 IPR002403 Cytochrome P450, E-class, group IV PRINTS PR00385 1.3E-7 342 353 IPR001128 Cytochrome P450 PRINTS PR00465 2.8E-38 375 389 IPR002403 Cytochrome P450, E-class, group IV PRINTS PR00465 2.8E-38 391 409 IPR002403 Cytochrome P450, E-class, group IV PRINTS PR00465 2.8E-38 417 433 IPR002403 Cytochrome P450, E-class, group IV PRINTS PR00385 1.3E-7 424 433 IPR001128 Cytochrome P450 ProSitePatterns PS00086 NA 426 435 IPR017972 Cytochrome P450, conserved site PRINTS PR00385 1.3E-7 433 444 IPR001128 Cytochrome P450 PRINTS PR00465 2.8E-38 433 451 IPR002403 Cytochrome P450, E-class, group IV
Subcellular Localization
Localization	endoplasmic reticulum
Evidence	SUBAcon
Pubmed ID	23180787