Basic information
Locus name	AT4G21470
Alias	ATFMN/FHY
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Others
Effect for Senescence	unclear
Gene Description	riboflavin kinase/FMN hydrolase (ATFMN/FHY); FUNCTIONS IN: riboflavin kinase activity, FMN adenylyltransferase activity; INVOLVED IN: riboflavin biosynthetic process, metabolic process; LOCATED IN: endomembrane system; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Haloacid dehalogenase-like hydrolase (InterPro:IPR005834), Haloacid dehydrogenase/epoxide hydrolase (InterPro:IPR005833), Riboflavin kinase (InterPro:IPR015865), HAD-superfamily hydrolase, subfamily IA, variant 3 (InterPro:IPR006402); BEST Arabidopsis thaliana protein match is: GPP1 (glycerol-3-phosphatase 1); catalytic/ hydrolase (TAIR:AT4G25840.1).
Evidence	Genomic evidence:microarray data [Ref 1]
References	1: Breeze E, Harrison E, McHattie S, Hughes L, Hickman R, Hill C, Kiddle S, Kim YS, Penfold CA, Jenkins D, Zhang C, Morris K, Jenner C, Jackson S, Thomas B, Tabrett A, Legaie R, Moore JD, Wild DL, Ott S, Rand D, Beynon J, Denby K, Mead A, Buchanan-Wollaston High-resolution temporal profiling of transcripts during Arabidopsis leaf senescence reveals a distinct chronology of processes and regulation. Plant Cell 2011 Mar;23(3):873-94
Gene Ontology	biological process metabolic process molecular function hydrolase activity
Pathway	KEGG map00740 (EC 2.7.1.26) MetaCyc PWY-5523
Sequence	AT4G21470.1 | Genomic | mRNA | CDS | Protein
Microarray
Sampling	Buchanan-Wollaston V, Page T, Harrison E, Breeze E, Lim PO, Nam HG, Lin JF, Wu SH, Swidzinski J, Ishizaki K, Leaver CJ. Comparative transcriptome analysis reveals significant differences in gene expression and signalling pathways between developmental and dark/starvation-induced senescence in Arabidopsis. Plant J. 2005 May;42(4)
Comparation	Legends: Col: wild type, indicates the ratio of expression in senescing leaves/green leaves. NahG, coi1 and ein2: indicates the ratio of expression in senescing leaves of mutant/senescing wild type. D/L: ratio of DARK 5d/control. CD: Cell Death, ratio of starved cell suspension culture/control. Genes showing at least 3 fold (ratio) up regulation during leaf senescence.
Ortholog Group
Ortholog Groups: OG5_127161	Accession Taxon NP_193878 ( AT4G21470 ) Arabidopsis thaliana NP_568192 Arabidopsis thaliana NP_568429 Arabidopsis thaliana NP_974751 Arabidopsis thaliana CMJ229C Cyanidioschyzon merolae strain 10D CMT190C Cyanidioschyzon merolae strain 10D 128353 Chlamydomonas reinhardtii 152228 Chlamydomonas reinhardtii ACO63042 Micromonas sp. RCC299 ACO69991 Micromonas sp. RCC299 NP_001051594 Oryza sativa Japonica Group NP_001064321 Oryza sativa Japonica Group NP_001064794 Oryza sativa Japonica Group e_gw1.01.00.401.1 Ostreococcus tauri fgenesh1_pg.C_Chr_08.0001000127 Ostreococcus tauri e_gw1.150.36.1 Physcomitrella patens subsp. patens estExt_Genewise1.C_790085 Physcomitrella patens subsp. patens fgenesh1_pg.scaffold_229000044 Physcomitrella patens subsp. patens 29933.m001421 Ricinus communis 30180.m001067 Ricinus communis estExt_thaps1_ua_kg.C_chr_100029 Thalassiosira pseudonana CCMP1335 fgenesh1_pg.C_chr_5000217 Thalassiosira pseudonana CCMP1335 XP_002947022 Volvox carteri f. nagariensis
Cross Link
Database Entry ID E-value Start End InterPro ID Description PANTHER PTHR22749 2.9E-97 1 377 IPR023468 Riboflavin kinase PRINTS PR00413 9.3E-7 11 22 IPR005833 Haloacid dehalogenase/epoxide hydrolase SUPERFAMILY SSF56784 2.0E-43 13 216 IPR023214 HAD-like domain Pfam PF13419 2.2E-25 14 192 IPR023214 HAD-like domain TIGRFAM TIGR01509 3.0E-14 92 193 IPR006402 HAD-superfamily hydrolase, subfamily IA, variant 3 PRINTS PR00413 9.3E-7 105 118 IPR005833 Haloacid dehalogenase/epoxide hydrolase TIGRFAM TIGR01549 8.3E-6 108 187 IPR006439 HAD-superfamily hydrolase, subfamily IA, variant 1 PRINTS PR00413 9.3E-7 137 153 IPR005833 Haloacid dehalogenase/epoxide hydrolase PRINTS PR00413 9.3E-7 155 175 IPR005833 Haloacid dehalogenase/epoxide hydrolase SMART SM00904 1.1E-40 234 364 IPR015865 Riboflavin kinase domain, bacterial/eukaryotic Pfam PF01687 2.7E-36 237 363 IPR015865 Riboflavin kinase domain, bacterial/eukaryotic SUPERFAMILY SSF82114 4.4E-44 238 376 IPR015865 Riboflavin kinase domain, bacterial/eukaryotic