Basic information
Locus name	AT4G01610
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Nutrient recycling:cysteine protease
Effect for Senescence	Unclear
Gene Description	Cathepsin B-like cysteine protease. Upregulated in senescent leaves.
Evidence	Molecular evidence: SSH and Northern [Ref 1]; Genomic evidence:microarray data [Ref 2]
References	1: Gepstein S, Sabehi G, Carp MJ, Hajouj T, Nesher MF, Yariv I, Dor C, Bassani M Large-scale identification of leaf senescence-associated genes. Plant J. 2003 Dec;36(5):629-42 2: Buchanan-Wollaston V, Page T, Harrison E, Breeze E, Lim PO, Nam HG, Lin JF, Wu SH, Swidzinski J, Ishizaki K, Leaver CJ Comparative transcriptome analysis reveals significant differences in gene expression and signalling pathways between developmental and dark/starvation-induced senescence in Arabidopsis. Plant J. 2005 May;42(4):567-85
Gene Ontology	biological process proteolysis molecular function cysteine-type peptidase activity
Sequence	AT4G01610.1 | Genomic | mRNA | CDS | Protein AT4G01610.2 | Genomic | mRNA | CDS | Protein
Microarray
Sampling	Buchanan-Wollaston V, Page T, Harrison E, Breeze E, Lim PO, Nam HG, Lin JF, Wu SH, Swidzinski J, Ishizaki K, Leaver CJ. Comparative transcriptome analysis reveals significant differences in gene expression and signalling pathways between developmental and dark/starvation-induced senescence in Arabidopsis. Plant J. 2005 May;42(4)
Comparation	Legends: Col: wild type, indicates the ratio of expression in senescing leaves/green leaves. NahG, coi1 and ein2: indicates the ratio of expression in senescing leaves of mutant/senescing wild type. D/L: ratio of DARK 5d/control. CD: Cell Death, ratio of starved cell suspension culture/control. Genes showing at least 3 fold (ratio) up regulation during leaf senescence.
miRNA Interaction
Details	target: AT4G01610.1  miRNA: ath-miR773 miRNA: ath-miR773 mfe: -24.9 kcal/mol  p-value: 0.028743  position:  1087  target 5' U  A                 U 3'             GG ACAGAGGCUGG GGUGA              UC UGUUUUCGACC UCGUU   miRNA  3' C              U     U 5'  target: AT4G01610.2  miRNA: ath-miR773 miRNA: ath-miR773 mfe: -24.9 kcal/mol  p-value: 0.028743  position:  1087  target 5' U  A                 U 3'             GG ACAGAGGCUGG GGUGA              UC UGUUUUCGACC UCGUU   miRNA  3' C              U     U 5'
Ortholog Group
Ortholog Groups: OG5_127800	Accession Taxon NP_563647 Arabidopsis thaliana NP_563648 Arabidopsis thaliana NP_567215 ( AT4G01610 ) Arabidopsis thaliana NP_849281 Arabidopsis thaliana 185887 Chlamydomonas reinhardtii ACO67014 Micromonas sp. RCC299 NP_001055157 Oryza sativa Japonica Group 1400010149 Ostreococcus tauri estExt_fgenesh1_pg.C_Chr_06.00010106 Ostreococcus tauri estExt_Genewise1.C_580031 Physcomitrella patens subsp. patens estExt_Genewise1.C_790115 Physcomitrella patens subsp. patens estExt_fgenesh1_pm.C_70048 Physcomitrella patens subsp. patens 30076.m004510 Ricinus communis
Cross Link
Database Entry ID E-value Start End InterPro ID Description Pfam PF08127 1.4E-14 43 85 IPR012599 Peptidase C1A, propeptide Pfam PF08127 1.4E-14 43 85 IPR012599 Peptidase C1A, propeptide PANTHER PTHR12411 2.4E-130 44 347 IPR013128 Peptidase C1A, papain PANTHER PTHR12411 1.9E-133 44 347 IPR013128 Peptidase C1A, papain SUPERFAMILY SSF54001 6.7E-90 44 339 No hit NA SUPERFAMILY SSF54001 5.3E-93 44 339 No hit NA Pfam PF00112 6.8E-64 103 337 IPR000668 Peptidase C1A, papain C-terminal Pfam PF00112 3.9E-66 103 337 IPR000668 Peptidase C1A, papain C-terminal SMART SM00645 6.8E-83 103 338 IPR000668 Peptidase C1A, papain C-terminal SMART SM00645 1.3E-87 103 338 IPR000668 Peptidase C1A, papain C-terminal PRINTS PR00705 4.9E-7 125 140 IPR000668 Peptidase C1A, papain C-terminal PRINTS PR00705 4.7E-8 125 140 IPR000668 Peptidase C1A, papain C-terminal ProSitePatterns PS00139 NA 125 136 IPR000169 Cysteine peptidase, cysteine active site ProSitePatterns PS00639 NA 284 294 IPR025660 Cysteine peptidase, histidine active site ProSitePatterns PS00639 NA 284 294 IPR025660 Cysteine peptidase, histidine active site PRINTS PR00705 4.9E-7 286 296 IPR000668 Peptidase C1A, papain C-terminal PRINTS PR00705 4.7E-8 286 296 IPR000668 Peptidase C1A, papain C-terminal PRINTS PR00705 4.9E-7 302 308 IPR000668 Peptidase C1A, papain C-terminal PRINTS PR00705 4.7E-8 302 308 IPR000668 Peptidase C1A, papain C-terminal
Subcellular Localization
Localization	extracellular
Evidence	SUBAcon
Pubmed ID	23180787