Basic information
Locus name	AT4G05020
Alias	NDB2
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Others
Effect for Senescence	unclear
Gene Description	NAD(P)H dehydrogenase B2 (NDB2); FUNCTIONS IN: disulfide oxidoreductase activity, oxidoreductase activity, FAD binding; LOCATED IN: extrinsic to mitochondrial inner membrane, mitochondrion;
Evidence	Genomic evidence:microarray data [Ref 1]
References	1: Breeze E, Harrison E, McHattie S, Hughes L, Hickman R, Hill C, Kiddle S, Kim YS, Penfold CA, Jenkins D, Zhang C, Morris K, Jenner C, Jackson S, Thomas B, Tabrett A, Legaie R, Moore JD, Wild DL, Ott S, Rand D, Beynon J, Denby K, Mead A, Buchanan-Wollaston High-resolution temporal profiling of transcripts during Arabidopsis leaf senescence reveals a distinct chronology of processes and regulation. Plant Cell 2011 Mar;23(3):873-94
Gene Ontology	biological process oxidation-reduction process molecular function oxidoreductase activity
Sequence	AT4G05020.1 | Genomic | mRNA | CDS | Protein AT4G05020.2 | Genomic | mRNA | CDS | Protein
Microarray
Sampling	Buchanan-Wollaston V, Page T, Harrison E, Breeze E, Lim PO, Nam HG, Lin JF, Wu SH, Swidzinski J, Ishizaki K, Leaver CJ. Comparative transcriptome analysis reveals significant differences in gene expression and signalling pathways between developmental and dark/starvation-induced senescence in Arabidopsis. Plant J. 2005 May;42(4)
Comparation	Legends: Col: wild type, indicates the ratio of expression in senescing leaves/green leaves. NahG, coi1 and ein2: indicates the ratio of expression in senescing leaves of mutant/senescing wild type. D/L: ratio of DARK 5d/control. CD: Cell Death, ratio of starved cell suspension culture/control. Genes showing at least 3 fold (ratio) up regulation during leaf senescence.
Ortholog Group
Ortholog Groups: OG5_126960	Accession Taxon NP_179673 Arabidopsis thaliana NP_180560 Arabidopsis thaliana NP_193880 Arabidopsis thaliana NP_563783 Arabidopsis thaliana NP_567283 ( AT4G05020 ) Arabidopsis thaliana NP_567801 Arabidopsis thaliana CMF056C Cyanidioschyzon merolae strain 10D CMQ432C Cyanidioschyzon merolae strain 10D 133334 Chlamydomonas reinhardtii 195711 Chlamydomonas reinhardtii 195719 Chlamydomonas reinhardtii ACO63302 Micromonas sp. RCC299 ACO64003 Micromonas sp. RCC299 NP_001044694 Oryza sativa Japonica Group NP_001055220 Oryza sativa Japonica Group NP_001058394 Oryza sativa Japonica Group NP_001060003 Oryza sativa Japonica Group estExt_gwp_GeneWisePlus.C_Chr_02.00010578 Ostreococcus tauri e_gw1.82.45.1 Physcomitrella patens subsp. patens estExt_gwp_gw1.C_1200041 Physcomitrella patens subsp. patens estExt_gwp_gw1.C_280285 Physcomitrella patens subsp. patens estExt_gwp_gw1.C_360127 Physcomitrella patens subsp. patens estExt_gwp_gw1.C_650130 Physcomitrella patens subsp. patens 29681.m001361 Ricinus communis 29917.m001956 Ricinus communis 29933.m001426 Ricinus communis 29983.m003269 Ricinus communis 29983.m003270 Ricinus communis e_gw1.11a.54.1 Thalassiosira pseudonana CCMP1335 e_gw1.19b.4.1 Thalassiosira pseudonana CCMP1335 fgenesh1_pg.C_chr_6000516 Thalassiosira pseudonana CCMP1335 fgenesh1_pm.C_chr_11a000012 Thalassiosira pseudonana CCMP1335 XP_002952814 Volvox carteri f. nagariensis XP_002953151 Volvox carteri f. nagariensis XP_002953221 Volvox carteri f. nagariensis XP_002955192 Volvox carteri f. nagariensis
Cross Link
Database Entry ID E-value Start End InterPro ID Description PANTHER PTHR22915 1.3E-218 52 619 No hit NA SUPERFAMILY SSF51905 1.7E-28 58 276 No hit NA Pfam PF07992 4.2E-34 60 376 IPR023753 Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain PRINTS PR00368 5.7E-10 61 80 IPR013027 FAD-dependent pyridine nucleotide-disulphide oxidoreductase PRINTS PR00368 5.7E-10 163 181 IPR013027 FAD-dependent pyridine nucleotide-disulphide oxidoreductase Pfam PF00070 4.8E-13 224 307 IPR001327 Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain PRINTS PR00368 5.7E-10 224 242 IPR013027 FAD-dependent pyridine nucleotide-disulphide oxidoreductase SUPERFAMILY SSF51905 1.0E-20 224 377 No hit NA SUPERFAMILY SSF47473 1.5E-7 337 469 No hit NA PRINTS PR00368 5.7E-10 351 373 IPR013027 FAD-dependent pyridine nucleotide-disulphide oxidoreductase ProSiteProfiles PS50222 13.1 379 414 IPR002048 EF-hand domain SMART SM00054 3.9E-4 383 411 IPR002048 EF-hand domain ProSitePatterns PS00018 NA 392 404 IPR018247 EF-Hand 1, calcium-binding site Coils Coil NA 444 465 No hit NA
Subcellular Localization
Localization 1 Localization mitochondria Evidence Localization with GFP-fusion protein (GFP:cDNA) Pubmed ID 10737809
Localization 2 Localization mitochondrion Evidence SUBAcon Pubmed ID 23180787