Basic information
Locus name	AT3G19260
Alias	LOH2
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Others
Effect for Senescence	unclear
Gene Description	LAG ONE HOMOLOGUE 2 (LOH2); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: response to molecule of fungal origin; LOCATED IN: endoplasmic reticulum, Golgi apparatus, plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Longevity assurance, LAG1/LAC1 (InterPro:IPR016439), TRAM, LAG1 and CLN8 homology (InterPro:IPR006634); BEST Arabidopsis thaliana protein match is: LAG13 (LAG1 LONGEVITY ASSURANCE HOMOLOG 3) (TAIR:AT1G13580.2); Has 957 Blast hits to 957 proteins in 162 species: Archae - 0; Bacteria - 0; Metazoa - 524; Fungi - 203; Plants - 100; Viruses - 2; Other Eukaryotes - 128 (source: NCBI BLink).
Evidence	Genomic evidence:microarray data [Ref 1]
References	1: Breeze E, Harrison E, McHattie S, Hughes L, Hickman R, Hill C, Kiddle S, Kim YS, Penfold CA, Jenkins D, Zhang C, Morris K, Jenner C, Jackson S, Thomas B, Tabrett A, Legaie R, Moore JD, Wild DL, Ott S, Rand D, Beynon J, Denby K, Mead A, Buchanan-Wollaston High-resolution temporal profiling of transcripts during Arabidopsis leaf senescence reveals a distinct chronology of processes and regulation. Plant Cell 2011 Mar;23(3):873-94
Gene Ontology	cellular component integral to membrane
Pathway	Reactome REACT_22258
Sequence	AT3G19260.1 | Genomic | mRNA | CDS | Protein
Ortholog Group
Ortholog Groups: OG5_126838	Accession Taxon NP_001031037 Arabidopsis thaliana NP_001154368 Arabidopsis thaliana NP_172815 Arabidopsis thaliana NP_188557 ( AT3G19260 ) Arabidopsis thaliana NP_566769 Arabidopsis thaliana CMM258C Cyanidioschyzon merolae strain 10D 105088 Chlamydomonas reinhardtii 188598 Chlamydomonas reinhardtii 41962 Chlamydomonas reinhardtii ACO68499 Micromonas sp. RCC299 NP_001047244 Oryza sativa Japonica Group NP_001047999 Oryza sativa Japonica Group NP_001049639 Oryza sativa Japonica Group 0300010060 Ostreococcus tauri e_gw1.13.334.1 Physcomitrella patens subsp. patens e_gw1.137.38.1 Physcomitrella patens subsp. patens e_gw1.151.18.1 Physcomitrella patens subsp. patens e_gw1.24.72.1 Physcomitrella patens subsp. patens fgenesh1_pg.scaffold_83000067 Physcomitrella patens subsp. patens 29801.m003184 Ricinus communis 30174.m009049 Ricinus communis 36771.m000012 Ricinus communis estExt_fgenesh1_pg.C_chr_220152 Thalassiosira pseudonana CCMP1335 fgenesh1_pg.C_chr_22000151 Thalassiosira pseudonana CCMP1335 XP_002946440 Volvox carteri f. nagariensis XP_002954631 Volvox carteri f. nagariensis
Cross Link
Database Entry ID E-value Start End InterPro ID Description PIRSF PIRSF005225 2.1E-55 3 296 IPR016439 Longevity assurance, LAG1/LAC1 PANTHER PTHR12560 2.3E-101 18 296 No hit NA ProSiteProfiles PS50922 20.1 71 278 IPR006634 TRAM/LAG1/CLN8 homology domain SMART SM00724 2.6E-68 71 278 IPR006634 TRAM/LAG1/CLN8 homology domain Pfam PF03798 5.3E-38 73 270 IPR006634 TRAM/LAG1/CLN8 homology domain
Subcellular Localization
Localization	plasma membrane
Evidence	SUBAcon
Pubmed ID	23180787