Basic information
Locus name	AT4G30110
Alias	HMA2
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Others
Effect for Senescence	unclear
Gene Description	HMA2; FUNCTIONS IN: cadmium-transporting ATPase activity; INVOLVED IN: metabolic process, ATP biosynthetic process, metal ion transport; LOCATED IN: endomembrane system, integral to membrane, membrane; EXPRESSED IN: 11 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Heavy metal transport/detoxification protein (InterPro:IPR006121), ATPase, P-type, ATPase-associated region (InterPro:IPR008250), ATPase, P-type, heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating (InterPro:IPR006404), Heavy-metal-associated, conserved site (InterPro:IPR017969), ATPase, P-type, H+ transporting proton pump (InterPro:IPR000695), Haloacid dehalogenase-like hydrolase (InterPro:IPR005834), ATPase, P-type, heavy metal translocating (InterPro:IPR006416), ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter (InterPro:IPR001757), ATPase, P-type phosphorylation site (InterPro:IPR018303); BEST Arabidopsis thaliana protein match is: HMA4; cadmium ion transmembrane transporter/ cadmium-transporting ATPase/ zinc ion transmembrane transporter (TAIR:AT2G19110.1); Has 22715 Blast hits to 17948 proteins in 1842 species: Archae - 516; Bacteria - 12861; Metazoa - 3478; Fungi - 1636; Plants - 1220; Viruses - 5; Other Eukaryotes - 2999 (source: NCBI BLink).
Evidence	Genomic evidence:microarray data [Ref 1]
References	1: Breeze E, Harrison E, McHattie S, Hughes L, Hickman R, Hill C, Kiddle S, Kim YS, Penfold CA, Jenkins D, Zhang C, Morris K, Jenner C, Jackson S, Thomas B, Tabrett A, Legaie R, Moore JD, Wild DL, Ott S, Rand D, Beynon J, Denby K, Mead A, Buchanan-Wollaston High-resolution temporal profiling of transcripts during Arabidopsis leaf senescence reveals a distinct chronology of processes and regulation. Plant Cell 2011 Mar;23(3):873-94
Gene Ontology	biological process cation transport cellular component integral to membrane molecular function cation-transporting ATPase activity
Sequence	AT4G30110.1 | Genomic | mRNA | CDS | Protein
Ortholog Group
Ortholog Groups: OG5_131206	Accession Taxon NP_179501 Arabidopsis thaliana NP_194740 ( AT4G30110 ) Arabidopsis thaliana NP_194741 Arabidopsis thaliana NP_195444 Arabidopsis thaliana CMS330C Cyanidioschyzon merolae strain 10D 195998 Chlamydomonas reinhardtii ACO64685 Micromonas sp. RCC299 ACO66588 Micromonas sp. RCC299 NP_001058417 Oryza sativa Japonica Group NP_001059240 Oryza sativa Japonica Group e_gw1.02.00.37.1 Ostreococcus tauri e_gw1.237.34.1 Physcomitrella patens subsp. patens e_gw1.287.33.1 Physcomitrella patens subsp. patens e_gw1.53.128.1 Physcomitrella patens subsp. patens e_gw1.55.194.1 Physcomitrella patens subsp. patens 28664.m000102 Ricinus communis 29970.m000988 Ricinus communis thaps1_ua_kg.chr_3000035 Thalassiosira pseudonana CCMP1335 XP_002951422 Volvox carteri f. nagariensis
Cross Link
Database Entry ID E-value Start End InterPro ID Description PANTHER PTHR24093 0.0 1 710 IPR001757 Cation-transporting P-type ATPase SUPERFAMILY SSF55008 4.1E-10 4 73 IPR006121 Heavy metal-associated domain, HMA ProSiteProfiles PS50846 14.0 8 74 IPR006121 Heavy metal-associated domain, HMA SUPERFAMILY SSF81665 4.3E-17 102 194 No hit NA TIGRFAM TIGR01512 2.2E-101 140 481 No hit NA TIGRFAM TIGR01525 6.3E-182 140 693 IPR027256 Cation-transporting P-type ATPase, subfamily IB Pfam PF00122 3.4E-47 162 381 IPR008250 P-type ATPase, A domain TIGRFAM TIGR01494 1.4E-71 163 668 IPR001757 Cation-transporting P-type ATPase SUPERFAMILY SSF81653 4.8E-20 203 288 No hit NA PRINTS PR00119 8.2E-22 238 252 IPR001757 Cation-transporting P-type ATPase SUPERFAMILY SSF81665 4.3E-17 289 383 No hit NA Pfam PF00702 3.7E-43 385 604 IPR023214 HAD-like domain SUPERFAMILY SSF56784 3.9E-48 387 407 IPR023214 HAD-like domain PRINTS PR00119 8.2E-22 389 403 IPR001757 Cation-transporting P-type ATPase ProSitePatterns PS00154 NA 391 397 IPR018303 P-type ATPase, phosphorylation site SUPERFAMILY SSF56784 3.9E-48 449 691 IPR023214 HAD-like domain PRINTS PR00119 8.2E-22 535 545 IPR001757 Cation-transporting P-type ATPase PRINTS PR00120 1.9E-5 562 578 IPR001757 Cation-transporting P-type ATPase PRINTS PR00119 8.2E-22 590 609 IPR001757 Cation-transporting P-type ATPase PRINTS PR00120 1.9E-5 590 606 IPR001757 Cation-transporting P-type ATPase PRINTS PR00119 8.2E-22 614 626 IPR001757 Cation-transporting P-type ATPase PRINTS PR00120 1.9E-5 622 647 IPR001757 Cation-transporting P-type ATPase
Subcellular Localization
Localization	plasma membrane
Evidence	SUBAcon
Pubmed ID	23180787