Basic information
Locus name	AT4G30120
Alias	HMA3
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Others
Effect for Senescence	unclear
Gene Description	HEAVY METAL ATPASE 3 (HMA3); FUNCTIONS IN: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism; INVOLVED IN: ATP biosynthetic process, metal ion transport; LOCATED IN: membrane; CONTAINS InterPro DOMAIN/s: Heavy metal transport/detoxification protein (InterPro:IPR006121), ATPase, P-type, ATPase-associated region (InterPro:IPR008250), ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter (InterPro:IPR001757), ATPase, P-type phosphorylation site (InterPro:IPR018303); BEST Arabidopsis thaliana protein match is: HMA4; cadmium ion transmembrane transporter/ cadmium-transporting ATPase/ zinc ion transmembrane transporter (TAIR:AT2G19110.1); Has 15349 Blast hits to 15341 proteins in 1717 species: Archae - 387; Bacteria - 10214; Metazoa - 1411; Fungi - 863; Plants - 691; Viruses - 3; Other Eukaryotes - 1780 (source: NCBI BLink).
Evidence	Genomic evidence:microarray data [Ref 1]
References	1: Breeze E, Harrison E, McHattie S, Hughes L, Hickman R, Hill C, Kiddle S, Kim YS, Penfold CA, Jenkins D, Zhang C, Morris K, Jenner C, Jackson S, Thomas B, Tabrett A, Legaie R, Moore JD, Wild DL, Ott S, Rand D, Beynon J, Denby K, Mead A, Buchanan-Wollaston High-resolution temporal profiling of transcripts during Arabidopsis leaf senescence reveals a distinct chronology of processes and regulation. Plant Cell 2011 Mar;23(3):873-94
Gene Ontology	biological process cation transport cellular component integral to membrane molecular function cation-transporting ATPase activity
Sequence	AT4G30120.1 | Genomic | mRNA | CDS | Protein
Ortholog Group
Ortholog Groups: OG5_131206	Accession Taxon NP_179501 Arabidopsis thaliana NP_194740 Arabidopsis thaliana NP_194741 ( AT4G30120 ) Arabidopsis thaliana NP_195444 Arabidopsis thaliana CMS330C Cyanidioschyzon merolae strain 10D 195998 Chlamydomonas reinhardtii ACO64685 Micromonas sp. RCC299 ACO66588 Micromonas sp. RCC299 NP_001058417 Oryza sativa Japonica Group NP_001059240 Oryza sativa Japonica Group e_gw1.02.00.37.1 Ostreococcus tauri e_gw1.237.34.1 Physcomitrella patens subsp. patens e_gw1.287.33.1 Physcomitrella patens subsp. patens e_gw1.53.128.1 Physcomitrella patens subsp. patens e_gw1.55.194.1 Physcomitrella patens subsp. patens 28664.m000102 Ricinus communis 29970.m000988 Ricinus communis thaps1_ua_kg.chr_3000035 Thalassiosira pseudonana CCMP1335 XP_002951422 Volvox carteri f. nagariensis
Cross Link
Database Entry ID E-value Start End InterPro ID Description PANTHER PTHR24093 4.0E-212 5 542 IPR001757 Cation-transporting P-type ATPase SUPERFAMILY SSF55008 9.3E-11 11 84 IPR006121 Heavy metal-associated domain, HMA ProSiteProfiles PS50846 14.3 14 80 IPR006121 Heavy metal-associated domain, HMA TIGRFAM TIGR01525 1.3E-114 146 541 IPR027256 Cation-transporting P-type ATPase, subfamily IB SUPERFAMILY SSF81665 9.3E-14 148 200 No hit NA Pfam PF00122 5.5E-44 169 387 IPR008250 P-type ATPase, A domain TIGRFAM TIGR01494 5.4E-38 169 412 IPR001757 Cation-transporting P-type ATPase SUPERFAMILY SSF81653 4.6E-19 208 294 No hit NA PRINTS PR00119 6.1E-5 244 258 IPR001757 Cation-transporting P-type ATPase SUPERFAMILY SSF81665 9.3E-14 295 389 No hit NA Pfam PF00702 1.8E-14 391 542 IPR023214 HAD-like domain PRINTS PR00119 6.1E-5 395 409 IPR001757 Cation-transporting P-type ATPase ProSitePatterns PS00154 NA 397 403 IPR018303 P-type ATPase, phosphorylation site SUPERFAMILY SSF81660 7.2E-17 397 524 IPR023299 P-type ATPase, cytoplasmic domain N
Subcellular Localization
Localization	vacuole,plasma membrane
Evidence	SUBAcon
Pubmed ID	23180787