Basic information
Locus name	AT5G07440
Alias	GDH2
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Redox regulation
Effect for Senescence	unclear
Gene Description	GLUTAMATE DEHYDROGENASE 2 (GDH2); FUNCTIONS IN: oxidoreductase activity, glutamate dehydrogenase [NAD(P)+] activity, glutamate dehydrogenase activity, ATP binding; INVOLVED IN: response to cadmium ion, response to salt stress; LOCATED IN: mitochondrion, plasma membrane; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Glutamate/phenylalanine/leucine/valine dehydrogenase (InterPro:IPR006095), Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal (InterPro:IPR006096), Glutamate dehydrogenase (InterPro:IPR014362), NAD(P)-binding (InterPro:IPR016040), Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation region (InterPro:IPR006097); BEST Arabidopsis thaliana protein match is: GDH1 (GLUTAMATE DEHYDROGENASE 1); ATP binding / glutamate dehydrogenase [NAD(P)+]/ oxidoreductase (TAIR:AT5G18170.1); Has 5757 Blast hits to 5752 proteins in 1260 species: Archae - 189; Bacteria - 2757; Metazoa - 311; Fungi - 155; Plants - 249; Viruses - 0; Other Eukaryotes - 2096 (source: NCBI BLink).
Evidence	Genomic evidence:microarray data [Ref 1]
References	1: Breeze E, Harrison E, McHattie S, Hughes L, Hickman R, Hill C, Kiddle S, Kim YS, Penfold CA, Jenkins D, Zhang C, Morris K, Jenner C, Jackson S, Thomas B, Tabrett A, Legaie R, Moore JD, Wild DL, Ott S, Rand D, Beynon J, Denby K, Mead A, Buchanan-Wollaston High-resolution temporal profiling of transcripts during Arabidopsis leaf senescence reveals a distinct chronology of processes and regulation. Plant Cell 2011 Mar;23(3):873-94
Gene Ontology	biological process cellular amino acid metabolic process oxidation-reduction process molecular function oxidoreductase activity
Sequence	AT5G07440.1 | Genomic | mRNA | CDS | Protein AT5G07440.2 | Genomic | mRNA | CDS | Protein AT5G07440.3 | Genomic | mRNA | CDS | Protein
Ortholog Group
Ortholog Groups: OG5_126857	Accession Taxon NP_001119183 ( AT5G07440 ) Arabidopsis thaliana NP_001119184 Arabidopsis thaliana NP_175583 Arabidopsis thaliana NP_187041 Arabidopsis thaliana NP_196361 Arabidopsis thaliana NP_197318 Arabidopsis thaliana CML049C Cyanidioschyzon merolae strain 10D CMM119C Cyanidioschyzon merolae strain 10D 137469 Chlamydomonas reinhardtii 82916 Chlamydomonas reinhardtii NP_001043333 Oryza sativa Japonica Group NP_001047589 Oryza sativa Japonica Group NP_001051540 Oryza sativa Japonica Group NP_001053457 Oryza sativa Japonica Group e_gw1.142.67.1 Physcomitrella patens subsp. patens e_gw1.204.56.1 Physcomitrella patens subsp. patens e_gw1.62.107.1 Physcomitrella patens subsp. patens e_gw1.7.53.1 Physcomitrella patens subsp. patens estExt_gwp_gw1.C_1430081 Physcomitrella patens subsp. patens estExt_gwp_gw1.C_340326 Physcomitrella patens subsp. patens fgenesh1_pg.scaffold_28000058 Physcomitrella patens subsp. patens 29950.m001132 Ricinus communis 30146.m003425 Ricinus communis 30147.m014355 Ricinus communis e_gw1.19c.8.1 Thalassiosira pseudonana CCMP1335 estExt_fgenesh1_pm.C_chr_40020 Thalassiosira pseudonana CCMP1335 XP_002953152 Volvox carteri f. nagariensis XP_002954776 Volvox carteri f. nagariensis
Cross Link
Database Entry ID E-value Start End InterPro ID Description PANTHER PTHR11606 9.9E-145 1 297 No hit NA SUPERFAMILY SSF53223 1.1E-58 5 178 No hit NA Pfam PF02812 6.4E-46 33 160 IPR006097 Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain PRINTS PR00082 1.6E-29 88 102 IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase ProSitePatterns PS00074 NA 96 109 IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase PRINTS PR00082 1.6E-29 167 189 IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase Pfam PF00208 2.2E-33 176 298 IPR006096 Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal SUPERFAMILY SSF51735 5.6E-37 176 298 No hit NA SMART SM00839 1.8E-13 178 309 IPR006096 Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal PRINTS PR00082 1.6E-29 209 229 IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase
Subcellular Localization
Localization 1 Localization mitochondria Evidence Localization with GFP-fusion protein (GFP:cDNA) Pubmed ID 10737809
Localization 2 Localization mitochondrion Evidence SUBAcon Pubmed ID 23180787