Basic information
Locus name	AT5G12200
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Others
Effect for Senescence	unclear
Gene Description	dihydropyrimidinase / DHPase / dihydropyrimidine amidohydrolase / hydantoinase (PYD2); FUNCTIONS IN: hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, dihydropyrimidinase activity; LOCATED IN: endomembrane system; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: D-hydantoinase (InterPro:IPR011778), Amidohydrolase 1 (InterPro:IPR006680), Metal-dependent hydrolase, composite (InterPro:IPR011059); BEST Arabidopsis thaliana protein match is: ATALN (Arabidopsis allantoinase); allantoinase/ hydrolase (TAIR:AT4G04955.1); Has 7799 Blast hits to 7784 proteins in 1206 species: Archae - 191; Bacteria - 3354; Metazoa - 592; Fungi - 130; Plants - 44; Viruses - 0; Other Eukaryotes - 3488 (source: NCBI BLink).
Evidence	Genomic evidence:microarray data [Ref 1]
References	1: Breeze E, Harrison E, McHattie S, Hughes L, Hickman R, Hill C, Kiddle S, Kim YS, Penfold CA, Jenkins D, Zhang C, Morris K, Jenner C, Jackson S, Thomas B, Tabrett A, Legaie R, Moore JD, Wild DL, Ott S, Rand D, Beynon J, Denby K, Mead A, Buchanan-Wollaston High-resolution temporal profiling of transcripts during Arabidopsis leaf senescence reveals a distinct chronology of processes and regulation. Plant Cell 2011 Mar;23(3):873-94
Gene Ontology	biological process pyrimidine nucleobase catabolic process cellular component cytoplasm molecular function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Pathway	Reactome REACT_18266
Sequence	AT5G12200.1 | Genomic | mRNA | CDS | Protein
Ortholog Group
Ortholog Groups: OG5_127801	Accession Taxon NP_568258 ( AT5G12200 ) Arabidopsis thaliana 97227 Chlamydomonas reinhardtii ACO70300 Micromonas sp. RCC299 NP_001044573 Oryza sativa Japonica Group e_gw1.101.22.1 Physcomitrella patens subsp. patens 29868.m000353 Ricinus communis XP_002950639 Volvox carteri f. nagariensis
Cross Link
Database Entry ID E-value Start End InterPro ID Description PANTHER PTHR11647 4.7E-291 30 522 No hit NA SUPERFAMILY SSF51338 1.3E-31 46 97 IPR011059 Metal-dependent hydrolase, composite domain TIGRFAM TIGR02033 5.5E-191 47 497 IPR011778 Hydantoinase/dihydropyrimidinase Pfam PF13147 1.8E-16 89 437 No hit NA SUPERFAMILY SSF51556 1.3E-94 98 426 No hit NA SUPERFAMILY SSF51338 1.3E-31 426 497 IPR011059 Metal-dependent hydrolase, composite domain
Subcellular Localization
Localization	endoplasmic reticulum
Evidence	SUBAcon
Pubmed ID	23180787