Basic information
Locus name	AT3G55610
Alias	P5CS2
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Others
Effect for Senescence	unclear
Gene Description	DELTA 1-PYRROLINE-5-CARBOXYLATE SYNTHASE 2 (P5CS2); FUNCTIONS IN: oxidoreductase activity, glutamate-5-semialdehyde dehydrogenase activity, catalytic activity, glutamate 5-kinase activity; INVOLVED IN: embryonic development ending in seed dormancy, hyperosmotic salinity response, proline biosynthetic process, response to abscisic acid stimulus; LOCATED IN: chloroplast, cytoplasm; EXPRESSED IN: 16 plant structures; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage, C globular stage, E expanded cotyledon stage, D bilateral stage; CONTAINS InterPro DOMAIN/s: Glutamate 5-kinase (InterPro:IPR001057), Aspartate/glutamate/uridylate kinase (InterPro:IPR001048), Aldehyde dehydrogenase, N-terminal (InterPro:IPR016162), Aldehyde dehydrogenase, C-terminal (InterPro:IPR016163), Aldehyde/histidinol dehydrogenase (InterPro:IPR016161), Gamma-glutamyl phosphate reductase GPR (InterPro:IPR000965), delta l-pyrroline-5-carboxylate synthetase (InterPro:IPR005766), Glutamate 5-kinase, ProB-related (InterPro:IPR005715); BEST Arabidopsis thaliana protein match is: P5CS1 (DELTA1-PYRROLINE-5-CARBOXYLATE SYNTHASE 1); delta1-pyrroline-5-carboxylate synthetase (TAIR:AT2G39800.1); Has 10582 Blast hits to 10574 proteins in 1356 species: Archae - 93; Bacteria - 5216; Metazoa - 129; Fungi - 176; Plants - 115; Viruses - 0; Other Eukaryotes - 4853 (source: NCBI BLink).
Evidence	Genomic evidence:microarray data [Ref 1]
References	1: Breeze E, Harrison E, McHattie S, Hughes L, Hickman R, Hill C, Kiddle S, Kim YS, Penfold CA, Jenkins D, Zhang C, Morris K, Jenner C, Jackson S, Thomas B, Tabrett A, Legaie R, Moore JD, Wild DL, Ott S, Rand D, Beynon J, Denby K, Mead A, Buchanan-Wollaston High-resolution temporal profiling of transcripts during Arabidopsis leaf senescence reveals a distinct chronology of processes and regulation. Plant Cell 2011 Mar;23(3):873-94
Gene Ontology	biological process proline biosynthetic process molecular function glutamate 5-kinase activity
Pathway	Reactome REACT_13 KEGG map00330 (EC 2.7.2.11) map00330 (EC 1.2.1.41)
Sequence	AT3G55610.1 | Genomic | mRNA | CDS | Protein AT3G55610.2 | Genomic | mRNA | CDS | Protein
Ortholog Group
Ortholog Groups: OG5_127763	Accession Taxon NP_001118846 Arabidopsis thaliana NP_181510 Arabidopsis thaliana NP_191120 ( AT3G55610 ) Arabidopsis thaliana NP_973641 Arabidopsis thaliana CMQ024C Cyanidioschyzon merolae strain 10D 130812 Chlamydomonas reinhardtii ACO65140 Micromonas sp. RCC299 NP_001044802 Oryza sativa Japonica Group NP_001055723 Oryza sativa Japonica Group gw1.10.00.92.1 Ostreococcus tauri e_gw1.22.25.1 Physcomitrella patens subsp. patens 30143.m001194 Ricinus communis estExt_gwp_gw1.C_chr_60294 Thalassiosira pseudonana CCMP1335 XP_002954612 Volvox carteri f. nagariensis
Cross Link
Database Entry ID E-value Start End InterPro ID Description PANTHER PTHR11063 0.0 1 621 No hit NA TIGRFAM TIGR01092 0.0 8 621 IPR005766 Delta l-pyrroline-5-carboxylate synthetase Pfam PF00696 2.4E-35 15 260 IPR001048 Aspartate/glutamate/uridylate kinase SUPERFAMILY SSF53633 5.9E-53 15 282 IPR001048 Aspartate/glutamate/uridylate kinase TIGRFAM TIGR01027 9.8E-60 15 283 IPR005715 Glutamate 5-kinase/delta-1-pyrroline-5-carboxylate synthase PRINTS PR00474 1.8E-56 52 66 IPR001057 Glutamate/acetylglutamate kinase PRINTS PR00474 1.8E-56 96 124 IPR001057 Glutamate/acetylglutamate kinase PRINTS PR00474 1.8E-56 136 157 IPR001057 Glutamate/acetylglutamate kinase PRINTS PR00474 1.8E-56 175 202 IPR001057 Glutamate/acetylglutamate kinase ProSitePatterns PS00902 NA 232 249 IPR019797 Glutamate 5-kinase, conserved site PRINTS PR00474 1.8E-56 234 254 IPR001057 Glutamate/acetylglutamate kinase SUPERFAMILY SSF53720 5.5E-61 297 621 IPR016161 Aldehyde/histidinol dehydrogenase TIGRFAM TIGR00407 7.2E-97 302 621 IPR000965 Gamma-glutamyl phosphate reductase GPR
Subcellular Localization
Localization	cytosol
Evidence	SUBAcon
Pubmed ID	23180787