Basic information
Locus name	AT5G37780
Alias	CaM1
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Signal transduction
Effect for Senescence	promote
Gene Description	Calmodulin 1
Evidence	Genetic evidence [Ref 1]
References	1: Dai C, Lee Y, Lee IC, Nam HG, Kwak JM. Calmodulin 1 Regulates Senescence and ABA Response in Arabidopsis. Front Plant Sci. 2018 Jul 2;9:803. doi: 10.3389/fpls.2018.00803. eCollection 2018.
Gene Ontology	molecular function calcium ion binding
Sequence	AT5G37780.1 | Genomic | mRNA | CDS | Protein AT5G37780.2 | Genomic | mRNA | CDS | Protein AT5G37780.3 | Genomic | mRNA | CDS | Protein
Mutant information
Mutated 1 Mutant name amiRNA-CaM1 Mutant/Transgenic transgene Ecotype Col-0 Mutagenesis type RNAi
Mutated 2 Mutant name 35S::CaM1-GFP Mutant/Transgenic transgene Ecotype Col-0 Mutagenesis type transgenic
miRNA Interaction
Details	target: AT5G37780.1  miRNA: ath-miR414 miRNA: ath-miR414 mfe: -34.2 kcal/mol  p-value: 0.000073  position: 549  target 5' G               U     C  3'             UGAUGAUGAUGAUGA GAUGA                 ACUGCUACUACUACU CUACU      miRNA  3'                 U        5'  target: AT5G37780.2  miRNA: ath-miR414 miRNA: ath-miR414 mfe: -34.2 kcal/mol  p-value: 0.000080  position: 594  target 5' G               U     C  3'             UGAUGAUGAUGAUGA GAUGA                 ACUGCUACUACUACU CUACU      miRNA  3'                 U        5'  target: AT5G37780.3  miRNA: ath-miR414 miRNA: ath-miR414 mfe: -34.2 kcal/mol  p-value: 0.000085  position: 627  target 5' G               U     C  3'             UGAUGAUGAUGAUGA GAUGA                 ACUGCUACUACUACU CUACU      miRNA  3'                 U        5'
Ortholog Group
Ortholog Groups: OG5_211842	Accession Taxon NP_001154754 Arabidopsis thaliana NP_001154755 ( AT5G37780 ) Arabidopsis thaliana
Cross Link
Database Entry ID E-value Start End InterPro ID Description PANTHER PTHR23050 1.7E-109 1 149 No hit NA SUPERFAMILY SSF47473 4.1E-57 2 147 No hit NA ProSiteProfiles PS50222 16.8 8 43 IPR002048 EF-hand domain SMART SM00054 6.9E-8 12 40 IPR002048 EF-hand domain Pfam PF13499 7.3E-15 14 73 IPR011992 EF-hand-like domain ProSitePatterns PS00018 NA 21 33 IPR018247 EF-Hand 1, calcium-binding site ProSiteProfiles PS50222 14.5 44 79 IPR002048 EF-hand domain SMART SM00054 1.8E-8 48 76 IPR002048 EF-hand domain ProSitePatterns PS00018 NA 57 69 IPR018247 EF-Hand 1, calcium-binding site ProSiteProfiles PS50222 17.6 81 116 IPR002048 EF-hand domain SMART SM00054 3.1E-8 85 113 IPR002048 EF-hand domain Pfam PF13499 1.6E-21 86 146 IPR011992 EF-hand-like domain ProSitePatterns PS00018 NA 94 106 IPR018247 EF-Hand 1, calcium-binding site ProSiteProfiles PS50222 15.4 117 149 IPR002048 EF-hand domain SMART SM00054 4.0E-9 121 149 IPR002048 EF-hand domain ProSitePatterns PS00018 NA 130 142 IPR018247 EF-Hand 1, calcium-binding site
Mutant Image
Yellowing of leaves, accumulation of reactive oxygen species (ROS), and expression of the senescence-associated gene 12 (SAG12) were significantly enhanced in CaM1 overexpression plants. In contrast, abscisic acid (ABA)-triggered ROS production and stomatal closure were reduced in amiRNA-CaM1 plants.
Subcellular Localization
Localization 1 Localization cytosol,plasma membrane Evidence SUBAcon Pubmed ID 23180787
Localization 2 Localization nucleus Evidence SUBAcon Pubmed ID 23180787