Basic information
Locus name	AT5G03280
Alias	EIN2
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Hormone response pathway:ET
Effect for Senescence	promote
Gene Description	Involved in ethylene signal transduction. Acts downstream of CTR1. Positively regulates ORE1 and negatively regulates mir164A,B,C to regulate leaf senescence.
Evidence	Genetic evidence:Mutant [Ref 1]
References	1: Kim JH, Woo HR, Kim J, Lim PO, Lee IC, Choi SH, Hwang D, Nam HG Trifurcate feed-forward regulation of age-dependent cell death involving miR164 in Arabidopsis. Science 2009 Feb 20;323(5917):1053-7
Gene Ontology	biological process transport cellular component membrane molecular function transporter activity
Pathway	Reactome REACT_15518
Sequence	AT5G03280.1 | Genomic | mRNA | CDS | Protein
Mutant information
Mutated 1 Mutant name ore3 Mutant/Transgenic mutant Ecotype Col-0 Mutagenesis type EMS
Mutated 2 Mutant name ein2-34 Mutant/Transgenic mutant Ecotype Col-0 Mutagenesis type EMS
Mutated 3 Mutant name AAF-OXein2-5 Mutant/Transgenic transgenic Ecotype Col-0 Mutagenesis type cross
Mutated 4 Mutant name ein2-1/GVG:GmSARK Mutant/Transgenic mutant Ecotype Col-0 Mutagenesis type cross
Mutated 5 Mutant name ein2-5EIL1ox Mutant/Transgenic Double mutant Ecotype Col-0 Mutagenesis type cross
miRNA Interaction
Details	target: AT5G03280.1  miRNA: ath-miR854a miRNA: ath-miR854a mfe: -28.3 kcal/mol  p-value: 0.059681  position:  50  target 5' U   U    A        U     A 3'             CUC CUCU UCUCUAUC CUCGU              GAG GAGG AGGGAUAG GAGUA   miRNA  3'                         G 5'  target: AT5G03280.1  miRNA: ath-miR854b miRNA: ath-miR854b mfe: -28.3 kcal/mol  p-value: 0.052700  position:  50  target 5' U   U    A        U     A 3'             CUC CUCU UCUCUAUC CUCGU              GAG GAGG AGGGAUAG GAGUA   miRNA  3'                         G 5'  target: AT5G03280.1  miRNA: ath-miR854c miRNA: ath-miR854c mfe: -28.3 kcal/mol  p-value: 0.056671  position:  50  target 5' U   U    A        U     A 3'             CUC CUCU UCUCUAUC CUCGU              GAG GAGG AGGGAUAG GAGUA   miRNA  3'                         G 5'  target: AT5G03280.1  miRNA: ath-miR854d miRNA: ath-miR854d mfe: -28.3 kcal/mol  p-value: 0.066216  position:  50  target 5' U   U    A        U     A 3'             CUC CUCU UCUCUAUC CUCGU              GAG GAGG AGGGAUAG GAGUA   miRNA  3'                         G 5'  target: AT5G03280.1  miRNA: ath-miR854e miRNA: ath-miR854e mfe: -28.3 kcal/mol  p-value: 0.056286  position:  50  target 5' U   U    A        U     A 3'             CUC CUCU UCUCUAUC CUCGU              GAG GAGG AGGGAUAG GAGUA   miRNA  3'                         G 5'
Ortholog Group
Ortholog Groups: OG5_153355	Accession Taxon NP_195948 ( AT5G03280 ) Arabidopsis thaliana 196299 Chlamydomonas reinhardtii NP_001050996 Oryza sativa Japonica Group NP_001058920 Oryza sativa Japonica Group NP_001058922 Oryza sativa Japonica Group e_gw1.197.128.1 Physcomitrella patens subsp. patens e_gw1.54.248.1 Physcomitrella patens subsp. patens 30078.m002320 Ricinus communis XP_002954234 Volvox carteri f. nagariensis
Cross Link
Database Entry ID E-value Start End InterPro ID Description PIRSF PIRSF037378 0.0 1 1294 IPR017187 Ethylene-insensitive protein 2 PANTHER PTHR11706 0.0 2 626 IPR001046 Natural resistance-associated macrophage like Pfam PF01566 1.6E-88 38 390 IPR001046 Natural resistance-associated macrophage like PRINTS PR00447 1.0E-17 97 123 IPR001046 Natural resistance-associated macrophage like PRINTS PR00447 1.0E-17 125 144 IPR001046 Natural resistance-associated macrophage like PRINTS PR00447 1.0E-17 199 222 IPR001046 Natural resistance-associated macrophage like PRINTS PR00447 1.0E-17 301 320 IPR001046 Natural resistance-associated macrophage like PRINTS PR00447 1.0E-17 361 380 IPR001046 Natural resistance-associated macrophage like
Mutant Image
overexpression of EIN2C leads to early flowering and senescence.
Subcellular Localization
Localization	plasma membrane
Evidence	SUBAcon
Pubmed ID	23180787