Basic information
Locus name	AT1G66340
Alias	ETR1/EIN1
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Hormone response pathway:ET
Effect for Senescence	delay
Gene Description	Similar to prokaryote sensory transduction proteins. Mutant with a delayed senescence phenotype.
Evidence	Genetic evidence:Mutant [Ref 1]
References	1: Chang C, Kwok SF, Bleecker AB, Meyerowitz EM Arabidopsis ethylene-response gene ETR1: similarity of product to two-component regulators. Science 1993 Oct 22;262(5133):539-44
Gene Ontology	biological process ethylene mediated signaling pathway phosphorelay signal transduction system phosphorylation regulation of transcription, DNA-dependent signal transduction cellular component endoplasmic reticulum membrane molecular function phosphorelay response regulator activity phosphorelay sensor kinase activity protein histidine kinase activity transferase activity, transferring phosphorus-containing groups
Pathway	Reactome REACT_14797 REACT_1046
Sequence	AT1G66340.1 | Genomic | mRNA | CDS | Protein
Mutant information
Mutated 1 Mutant name etr1-1 Mutant/Transgenic mutant Ecotype Col-0 Mutagenesis type EMS
Mutated 2 Mutant name etr1-9;ers1-3 Mutant/Transgenic mutant Ecotype Col-0 Mutagenesis type T-DNA insertion_knock out
Mutated 3 Mutant name GVG::etr1-1 transgenic petunias Mutant/Transgenic transgenic Ecotype Petunia Mutagenesis type transgene
Ortholog Group
Ortholog Groups: OG5_130368	Accession Taxon NP_176808 ( AT1G66340 ) Arabidopsis thaliana NP_181626 Arabidopsis thaliana 179112 Chlamydomonas reinhardtii ACO69512 Micromonas sp. RCC299 NP_001051004 Oryza sativa Japonica Group NP_001054689 Oryza sativa Japonica Group estExt_Genewise1.C_540294 Physcomitrella patens subsp. patens estExt_fgenesh2_pg.C_1150032 Physcomitrella patens subsp. patens estExt_gwp_gw1.C_10269 Physcomitrella patens subsp. patens estExt_gwp_gw1.C_1760065 Physcomitrella patens subsp. patens fgenesh1_pg.scaffold_15000081 Physcomitrella patens subsp. patens fgenesh1_pm.scaffold_21000042 Physcomitrella patens subsp. patens fgenesh2_pg.scaffold_115000033 Physcomitrella patens subsp. patens gw1.145.89.1 Physcomitrella patens subsp. patens 28356.m000072 Ricinus communis 28802.m000134 Ricinus communis 29986.m001660 Ricinus communis XP_002952599 Volvox carteri f. nagariensis
Cross Link
Database Entry ID E-value Start End InterPro ID Description PIRSF PIRSF026389 0.0 1 736 IPR014525 Signal transduction histidine kinase, hybrid-type, ethylene sensor PANTHER PTHR24423 2.3E-85 13 736 No hit NA Pfam PF01590 2.3E-13 158 307 IPR003018 GAF domain SMART SM00065 1.2E-14 158 317 IPR003018 GAF domain SUPERFAMILY SSF55781 6.3E-11 161 310 No hit NA SUPERFAMILY SSF47384 1.4E-17 329 409 IPR009082 Signal transduction histidine kinase, homodimeric domain SMART SM00388 3.8E-20 343 408 IPR003661 Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain Pfam PF00512 6.2E-17 344 408 IPR003661 Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain ProSiteProfiles PS50109 46.0 350 585 IPR005467 Signal transduction histidine kinase, core SUPERFAMILY SSF55874 8.4E-38 397 581 IPR003594 Histidine kinase-like ATPase, ATP-binding domain Pfam PF02518 3.5E-27 455 581 IPR003594 Histidine kinase-like ATPase, ATP-binding domain SMART SM00387 3.5E-32 455 583 IPR003594 Histidine kinase-like ATPase, ATP-binding domain PRINTS PR00344 3.5E-10 507 521 IPR004358 Signal transduction histidine kinase-related protein, C-terminal PRINTS PR00344 3.5E-10 525 535 IPR004358 Signal transduction histidine kinase-related protein, C-terminal PRINTS PR00344 3.5E-10 542 560 IPR004358 Signal transduction histidine kinase-related protein, C-terminal SUPERFAMILY SSF52172 2.3E-27 606 730 IPR011006 CheY-like superfamily SMART SM00448 4.1E-15 610 725 IPR001789 Signal transduction response regulator, receiver domain ProSiteProfiles PS50110 21.1 611 729 IPR001789 Signal transduction response regulator, receiver domain Pfam PF00072 1.9E-12 612 724 IPR001789 Signal transduction response regulator, receiver domain
Mutant Image
CS6374. Loss-of-function of ETR1 leads to early senescence.
Subcellular Localization
Localization 1 Localization ER Evidence Localization with GFP-fusion protein (GFP:cDNA) Pubmed ID 10737809
Localization 2 Localization endoplasmic reticulum Evidence SUBAcon Pubmed ID 23180787