Basic information
Locus name	AT4G16110
Alias	ARR2
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Hormone response pathway:CK
Effect for Senescence	delay
Gene Description	Encodes a pollen-specific transcription factor involved in the expression of nuclear genes for components of mitochondrial complex I in Arabidopsis. Acts in concert with other type-B ARRs in the cytokinin signaling pathway. AHK3 mediates cytokinin-induced phosphorylation of ARR2 on the Asp-80 residue. This phosphorylation plays a positive role of ARR2 in cytokinin-mediated control of leaf longevity.
Evidence	Molecular evidence [Ref 1]; Genetic evidence:transgene [Ref 2]
References	1: Kim HJ, Ryu H, Hong SH, Woo HR, Lim PO, Lee IC, Sheen J, Nam HG, Hwang I Cytokinin-mediated control of leaf longevity by AHK3 through phosphorylation of ARR2 in Arabidopsis. Proc. Natl. Acad. Sci. U.S.A. 2006 Jan 17;103(3):814-9 2: Kim K, Ryu H, Cho YH, Scacchi E, Sabatini S, Hwang I Cytokinin-facilitated proteolysis of ARABIDOPSIS RESPONSE REGULATOR_2 attenuates signaling output in two-component circuitry. Plant J. 2012 Mar;69(6):934-45
Gene Ontology	biological process phosphorelay signal transduction system regulation of transcription, DNA-dependent molecular function chromatin binding phosphorelay response regulator activity
Pathway	Reactome REACT_14797
Sequence	AT4G16110.1 | Genomic | mRNA | CDS | Protein
Mutant information
Mutant name	ARR2K90G-HA ox
Mutant/Transgenic	transgenic
Ecotype	Col-0
Mutagenesis type	transgene
miRNA Interaction
Details	target: AT4G16110.1  miRNA: ath-miR404 miRNA: ath-miR404 mfe: -33.4 kcal/mol  p-value: 0.007289  position:  982  target 5' U        G    A     G      C 3'             GCUGCUGU AAUC GCUAG CGUUGA              CGACGGCG UUGG CGGUC GCAAUU   miRNA  3'                            A 5'
Ortholog Group
Ortholog Groups: OG5_141279	Accession Taxon NP_193346 ( AT4G16110 ) Arabidopsis thaliana NP_566561 Arabidopsis thaliana NP_850600 Arabidopsis thaliana 113139 Chlamydomonas reinhardtii ACO70013 Micromonas sp. RCC299 NP_001049427 Oryza sativa Japonica Group estExt_fgenesh1_pg.C_Chr_16.00010090 Ostreococcus tauri e_gw1.10.288.1 Physcomitrella patens subsp. patens e_gw1.16.93.1 Physcomitrella patens subsp. patens e_gw1.362.4.1 Physcomitrella patens subsp. patens 27647.m000179 Ricinus communis 29889.m003245 Ricinus communis fgenesh1_pg.C_chr_2000345 Thalassiosira pseudonana CCMP1335 XP_002958010 Volvox carteri f. nagariensis
Cross Link
Database Entry ID E-value Start End InterPro ID Description PIRSF PIRSF036392 0.0 4 661 IPR017053 Response regulator, plant B-type PANTHER PTHR26402 1.5E-62 27 352 No hit NA SUPERFAMILY SSF52172 9.4E-35 27 151 IPR011006 CheY-like superfamily SMART SM00448 6.5E-30 28 140 IPR001789 Signal transduction response regulator, receiver domain ProSiteProfiles PS50110 31.4 29 144 IPR001789 Signal transduction response regulator, receiver domain Pfam PF00072 8.0E-22 30 138 IPR001789 Signal transduction response regulator, receiver domain ProSiteProfiles PS51294 11.3 213 272 IPR017930 Myb domain SUPERFAMILY SSF46689 7.2E-20 214 273 IPR009057 Homeodomain-like TIGRFAM TIGR01557 2.5E-24 216 269 IPR006447 Myb domain, plants Pfam PF00249 2.2E-11 218 268 IPR001005 SANT/Myb domain
Subcellular Localization
Localization 1 Localization nucleus Evidence Localization with GFP-fusion protein (GFP:cDNA) Pubmed ID 10737809
Localization 2 Localization nucleus Evidence SUBAcon Pubmed ID 23180787