Basic information
Locus name	LOC_Os03g62110
Alias	OsNaPRT1
Organism	Rice (Oryza sativa)
Taxonomic identifier	[NCBI]
Function category	NAD
Effect for Senescence	delay
Gene Description	encoding O. sativa nicotinate phosphoribosyltransferase (OsNaPRT1) in the NAD salvage pathway
Evidence	Genetic evidence:Mutant [Ref 1]
References	1: Wu L, Ren D, Hu S, Li G, Dong G, Jiang L, Hu X, Ye W, Cui Y, Zhu L, Hu J, Zhang G, Gao Z, Zeng D, Qian Q, Guo L. Down-Regulation of a Nicotinate Phosphoribosyltransferase Gene, OsNaPRT1, Leads to Withered Leaf Tips. Plant Physiol. 2016 Jun;171(2):1085-98. doi: 10.1104/pp.15.01898. Epub 2016 Apr 5.
Sequence	LOC_Os03g62110.2 | mRNA | CDS | Protein LOC_Os03g62110.3 | mRNA | CDS | Protein
Mutant information
Mutant name	LTS1
Mutant/Transgenic	mutant
Ecotype	Rice (Oryza sativa)
Mutagenesis type	T-DNA
Mutant Image
A point mutation in OsNaPRT1 leads to dwarfism and the withered leaf tip phenotype, and the lts1 mutant displays early leaf senescence compared to the wild type. Leaf tissue of lts1 exhibited significant DNA fragmentation and H2O2 accumulation, along with up-regulation of genes associated with senescence. The lts1 mutant also showed reduced expression of SIR2-like genes (OsSRT1 and OsSRT2) and increased acetylation of histone H3K9. deficiency in the NAD salvage pathway can trigger premature�leafsenescence�.