Basic information
Locus name	At3g51860
Alias	CAX3
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	ROS
Effect for Senescence	delay
Gene Description	cation exchanger 3
Evidence	Genetic evidence [Ref 1]
References	1: Cheng NH, Pittman JK, Shigaki T, Lachmansingh J, LeClere S, Lahner B, Salt DE, Hirschi KD. Functional association of Arabidopsis CAX1 and CAX3 is required for normal growth and ion homeostasis. Plant Physiol. 2005 Aug;138(4):2048-60. Epub 2005 Jul 29.
Gene Ontology	biological process calcium ion transport cation transport transmembrane transport cellular component integral to membrane molecular function calcium:hydrogen antiporter activity
Pathway	Reactome REACT_15518
Sequence	AT3G51860.1 | mRNA | CDS | Protein AT3G51860.2 | mRNA | CDS | Protein
Ortholog Group
Ortholog Groups: OG5_128780	Accession Taxon NP_001031196 Arabidopsis thaliana NP_175968 Arabidopsis thaliana NP_175969 Arabidopsis thaliana NP_181352 Arabidopsis thaliana NP_190754 ( At3g51860 ) Arabidopsis thaliana NP_566452 Arabidopsis thaliana NP_850292 Arabidopsis thaliana NP_973630 Arabidopsis thaliana CMQ284C Cyanidioschyzon merolae strain 10D 105167 Chlamydomonas reinhardtii 119334 Chlamydomonas reinhardtii NP_001043331 Oryza sativa Japonica Group NP_001050301 Oryza sativa Japonica Group NP_001054105 Oryza sativa Japonica Group NP_001056506 Oryza sativa Japonica Group e_gw1.223.28.1 Physcomitrella patens subsp. patens e_gw1.79.173.1 Physcomitrella patens subsp. patens estExt_Genewise1.C_210062 Physcomitrella patens subsp. patens estExt_fgenesh1_pg.C_3360015 Physcomitrella patens subsp. patens estExt_gwp_gw1.C_2450012 Physcomitrella patens subsp. patens 29681.m001341 Ricinus communis 29701.m000596 Ricinus communis 30005.m001242 Ricinus communis e_gw1.6.195.1 Thalassiosira pseudonana CCMP1335 fgenesh1_pg.C_chr_9000236 Thalassiosira pseudonana CCMP1335 XP_002947557 Volvox carteri f. nagariensis XP_002949016 Volvox carteri f. nagariensis XP_002952192 Volvox carteri f. nagariensis XP_002953458 Volvox carteri f. nagariensis XP_002959140 Volvox carteri f. nagariensis
Cross Link
Database Entry ID E-value Start End InterPro ID Description PANTHER PTHR31503 3.1E-146 1 450 No hit NA TIGRFAM TIGR00846 3.1E-164 60 433 IPR004713 Calcium/proton exchanger TIGRFAM TIGR00378 2.9E-97 79 433 IPR004798 Calcium/proton exchanger CAX Pfam PF01699 4.7E-22 104 254 IPR004837 Sodium/calcium exchanger membrane region Pfam PF01699 1.0E-21 299 430 IPR004837 Sodium/calcium exchanger membrane region
Mutant Image
A cax1cax3 loss-of-function double mutant exhibits leaf growth defects and early senescence in the leaves when grown in soil and increased sensitivity to high Ca2+ concentrations when grown on agar medium
Subcellular Localization
Localization 1 Localization other cytoplasmic components Evidence Localization with GFP-fusion protein (GFP:cDNA) Pubmed ID 10737809
Localization 2 Localization plastid Evidence SUBAcon Pubmed ID 23180787