Basic information
Locus name	AT1G54115
Alias	CCX4
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Calcium exchanger
Effect for Senescence	promote
Gene Description	CATION CALCIUM EXCHANGER 4 is involved in cation (Na and K) homeostasis.
Evidence	Genetic evidence [Ref 1]
References	1: Li Z, Wang X, Chen J, Gao J, Zhou X, Kuai B. CCX1, a Putative Cation/Ca2+ Exchanger, Participates in Regulation of Reactive Oxygen Species Homeostasis and Leaf Senescence. Plant Cell Physiol. 2016 Dec;57(12):2611-2619. Epub 2016 Oct 25.
Gene Ontology	biological process transmembrane transport cellular component integral to membrane
Pathway	Reactome REACT_15518
Sequence	AT1G54115.1 | mRNA | CDS | Protein
Mutant information
Mutant name	ccx4 (SALK_040272)
Mutant/Transgenic	mutant
Ecotype	Col-0
Mutagenesis type	T-DNA
Ortholog Group
Ortholog Groups: OG5_127811	Accession Taxon NP_172370 Arabidopsis thaliana NP_197288 Arabidopsis thaliana NP_564650 ( AT1G54115 ) Arabidopsis thaliana NP_566474 Arabidopsis thaliana 196017 Chlamydomonas reinhardtii 205918 Chlamydomonas reinhardtii ACO63315 Micromonas sp. RCC299 ACO65591 Micromonas sp. RCC299 ACO66371 Micromonas sp. RCC299 NP_001049159 Oryza sativa Japonica Group NP_001050809 Oryza sativa Japonica Group NP_001064673 Oryza sativa Japonica Group NP_001067316 Oryza sativa Japonica Group 0400010445 Ostreococcus tauri estExt_fgenesh1_pg.C_Chr_05.00010047 Ostreococcus tauri e_gw1.1.499.1 Physcomitrella patens subsp. patens gw1.254.44.1 Physcomitrella patens subsp. patens gw1.90.152.1 Physcomitrella patens subsp. patens 27789.m000069 Ricinus communis 29739.m003745 Ricinus communis 30072.m000939 Ricinus communis 30128.m008749 Ricinus communis estExt_fgenesh1_pg.C_chr_10913 Thalassiosira pseudonana CCMP1335 estExt_fgenesh1_pg.C_chr_140125 Thalassiosira pseudonana CCMP1335 fgenesh1_pg.C_chr_17000029 Thalassiosira pseudonana CCMP1335 fgenesh1_pg.C_chr_6000011 Thalassiosira pseudonana CCMP1335 XP_002952446 Volvox carteri f. nagariensis XP_002952905 Volvox carteri f. nagariensis
Cross Link
Database Entry ID E-value Start End InterPro ID Description PANTHER PTHR12266 5.3E-162 26 644 No hit NA Pfam PF01699 3.1E-29 152 282 IPR004837 Sodium/calcium exchanger membrane region Pfam PF01699 9.3E-24 490 631 IPR004837 Sodium/calcium exchanger membrane region
Mutant Image
a member of the cation/Ca2+ exchanger family, CCX1, is highly induced during leaf senescence in Arabidopsis. Although single mutation of CCX1 did not change the senescence phenotype, double mutation of CCX1 and CCX4 resulted in a subtle but significant stay-green phenotype during natural and dark-induced leaf senescence, suggesting that some members of the cation/Ca2+ exchanger family act redundantly in mediating leaf senescence.
Subcellular Localization
Localization	plasma membrane
Evidence	SUBAcon
Pubmed ID	23180787