Basic information
Locus name	AT5G51070
Alias	ERD1/SAG15
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Others:Defense and cell rescue mechanisms
Effect for Senescence	unclear
Gene Description	ATP-dependent Clp protease regulatory subunit
Evidence	Genetic evidence:Mutant [Ref 1]
References	1: Nakashima K, Kiyosue T, Yamaguchi-Shinozaki K, Shinozaki K A nuclear gene, erd1, encoding a chloroplast-targeted Clp protease regulatory subunit homolog is not only induced by water stress but also developmentally up-regulated during senescence in Arabidopsis thaliana. Plant J. 1997 Oct;12(4):851-61
Gene Ontology	molecular function ATP binding
Sequence	AT5G51070.1 | Genomic | mRNA | CDS | Protein
Mutant information
Mutant name	erd1
Mutant/Transgenic	mutant
Ecotype	Col-0
Mutagenesis type	T-DNA insertion_knock out
Microarray
Sampling	Buchanan-Wollaston V, Page T, Harrison E, Breeze E, Lim PO, Nam HG, Lin JF, Wu SH, Swidzinski J, Ishizaki K, Leaver CJ. Comparative transcriptome analysis reveals significant differences in gene expression and signalling pathways between developmental and dark/starvation-induced senescence in Arabidopsis. Plant J. 2005 May;42(4)
Comparation	Legends: Col: wild type, indicates the ratio of expression in senescing leaves/green leaves. NahG, coi1 and ein2: indicates the ratio of expression in senescing leaves of mutant/senescing wild type. D/L: ratio of DARK 5d/control. CD: Cell Death, ratio of starved cell suspension culture/control. Genes showing at least 3 fold (ratio) up regulation during leaf senescence.
miRNA Interaction
Details	target: AT5G51070.1  miRNA: ath-miR161 miRNA: ath-miR161 mfe: -22.1 kcal/mol  p-value: 0.047014  position:  1421  target 5' G   G A              C 3'             GGU A C UUCAGUGCAUUG              UCA U G AAGUUACGUAAC   miRNA  3' A   G   A            U 5'
Ortholog Group
Ortholog Groups: OG5_126636	Accession Taxon NP_565083 Arabidopsis thaliana NP_565586 Arabidopsis thaliana NP_566912 Arabidopsis thaliana NP_567437 Arabidopsis thaliana NP_568314 Arabidopsis thaliana NP_568746 Arabidopsis thaliana NP_568750 ( AT5G51070 ) Arabidopsis thaliana CMC125C Cyanidioschyzon merolae strain 10D CMI251C Cyanidioschyzon merolae strain 10D CMS128C Cyanidioschyzon merolae strain 10D CMV107C Cyanidioschyzon merolae strain 10D 107731 Chlamydomonas reinhardtii 172454 Chlamydomonas reinhardtii 195417 Chlamydomonas reinhardtii 195422 Chlamydomonas reinhardtii 195423 Chlamydomonas reinhardtii ACO62257 Micromonas sp. RCC299 ACO65528 Micromonas sp. RCC299 ACO66808 Micromonas sp. RCC299 ACO68882 Micromonas sp. RCC299 NP_001046096 Oryza sativa Japonica Group NP_001046997 Oryza sativa Japonica Group NP_001050410 Oryza sativa Japonica Group NP_001052665 Oryza sativa Japonica Group NP_001056066 Oryza sativa Japonica Group NP_001066442 Oryza sativa Japonica Group NP_001067671 Oryza sativa Japonica Group e_gw1.07.00.42.1 Ostreococcus tauri estExt_fgenesh1_pg.C_Chr_14.00010074 Ostreococcus tauri estExt_genewise1.C_Chr_01.00010063 Ostreococcus tauri estExt_gwp_GeneWisePlus.C_Chr_05.00010425 Ostreococcus tauri e_gw1.23.107.1 Physcomitrella patens subsp. patens e_gw1.3.110.1 Physcomitrella patens subsp. patens e_gw1.62.104.1 Physcomitrella patens subsp. patens e_gw1.91.131.1 Physcomitrella patens subsp. patens estExt_Genewise1.C_3000044 Physcomitrella patens subsp. patens estExt_fgenesh1_pg.C_880113 Physcomitrella patens subsp. patens estExt_fgenesh1_pm.C_2520006 Physcomitrella patens subsp. patens estExt_fgenesh1_pm.C_810007 Physcomitrella patens subsp. patens estExt_gwp_gw1.C_1960009 Physcomitrella patens subsp. patens estExt_gwp_gw1.C_270106 Physcomitrella patens subsp. patens 29630.m000784 Ricinus communis 29848.m004552 Ricinus communis 30138.m003984 Ricinus communis 30147.m014373 Ricinus communis 30147.m014420 Ricinus communis e_gw1.18.13.1 Thalassiosira pseudonana CCMP1335 estExt_fgenesh1_pg.C_chr_90020 Thalassiosira pseudonana CCMP1335 estExt_gwp_gw1.C_chr_30158 Thalassiosira pseudonana CCMP1335 thaps1_ua_kg.chr_22000029 Thalassiosira pseudonana CCMP1335 XP_002946377 Volvox carteri f. nagariensis XP_002946539 Volvox carteri f. nagariensis XP_002947715 Volvox carteri f. nagariensis XP_002949981 Volvox carteri f. nagariensis XP_002950861 Volvox carteri f. nagariensis XP_002951745 Volvox carteri f. nagariensis XP_002952540 Volvox carteri f. nagariensis XP_002957032 Volvox carteri f. nagariensis
Cross Link
Database Entry ID E-value Start End InterPro ID Description PANTHER PTHR11638 0.0 68 923 No hit NA SUPERFAMILY SSF81923 2.5E-15 81 232 No hit NA Pfam PF02861 2.3E-8 94 143 IPR004176 Clp, N-terminal Pfam PF02861 6.3E-10 179 226 IPR004176 Clp, N-terminal SUPERFAMILY SSF52540 1.6E-62 270 527 IPR027417 P-loop containing nucleoside triphosphate hydrolase SMART SM00382 6.2E-10 308 457 IPR003593 AAA+ ATPase domain Pfam PF00004 1.7E-9 313 422 IPR003959 ATPase, AAA-type, core ProSitePatterns PS00870 NA 408 420 IPR018368 Chaperonin ClpA/B, conserved site SUPERFAMILY SSF52540 4.1E-75 605 922 IPR027417 P-loop containing nucleoside triphosphate hydrolase Pfam PF07724 3.4E-52 655 831 IPR013093 ATPase, AAA-2 SMART SM00382 1.3E-9 656 838 IPR003593 AAA+ ATPase domain PRINTS PR00300 4.9E-39 660 678 IPR001270 Chaperonin ClpA/B ProSitePatterns PS00871 NA 690 708 IPR001270 Chaperonin ClpA/B PRINTS PR00300 4.9E-39 705 723 IPR001270 Chaperonin ClpA/B PRINTS PR00300 4.9E-39 734 752 IPR001270 Chaperonin ClpA/B PRINTS PR00300 4.9E-39 767 781 IPR001270 Chaperonin ClpA/B Pfam PF10431 2.1E-22 837 915 IPR019489 Clp ATPase, C-terminal SMART SM01086 3.1E-30 837 927 IPR019489 Clp ATPase, C-terminal
Subcellular Localization
Localization 1 Localization chloroplast Evidence Localization with GFP-fusion protein (GFP:cDNA) Pubmed ID 10737809
Localization 2 Localization plastid Evidence SUBAcon Pubmed ID 23180787