Basic information
Locus name	AT2G43790
Alias	MPK6
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Signal transduction:MKK cascade
Effect for Senescence	promote
Gene Description	Encodes a MAP kinase induced by pathogens, ethylene biosynthesis, oxidative stress and osmotic stress.
Evidence	Genetic evidence:Mutant [Ref 1]
References	1: Zhou C, Cai Z, Guo Y, Gan S An arabidopsis mitogen-activated protein kinase cascade, MKK9-MPK6, plays a role in leaf senescence. Plant Physiol. 2009 May;150(1):167-77
Gene Ontology	biological process protein phosphorylation molecular function ATP binding MAP kinase activity protein kinase activity protein serine/threonine kinase activity
Sequence	AT2G43790.1 | Genomic | mRNA | CDS | Protein
Mutant information
Mutated 1 Mutant name mpk6-2 Mutant/Transgenic mutant Ecotype Col-0 Mutagenesis type T-DNA insertion_knock out
Mutated 2 Mutant name mpk6-3 Mutant/Transgenic mutant Ecotype Col-0 Mutagenesis type T-DNA insertion_knock out
Mutated 3 Mutant name 35S:MKK9mpk6 Mutant/Transgenic mutant and trangenic(Double mutant) Ecotype Col-0 Mutagenesis type cross
miRNA Interaction
Details	target: AT2G43790.1  miRNA: ath-miR159a miRNA: ath-miR159a mfe: -28.1 kcal/mol  p-value: 0.012740  position:  1323  target 5' G   C    G             A 3'             AGG GCUU CUUUCAAUCCAGA              UCU CGAG GGAAGUUAGGUUU   miRNA  3' A                        5'  target: AT2G43790.1  miRNA: ath-miR159b miRNA: ath-miR159b mfe: -28.6 kcal/mol  p-value: 0.010597  position:  1322  target 5' C    C    G             A 3'             GAGG GCUU CUUUCAAUCCAGA              UUCU CGAG GGAAGUUAGGUUU   miRNA  3'                           5'  target: AT2G43790.1  miRNA: ath-miR159c miRNA: ath-miR159c mfe: -30.5 kcal/mol  p-value: 0.005145  position:  1323  target 5' G   C    G             A 3'             AGG GCUU CUUUCAAUCCAGA              UCC CGAG GGAAGUUAGGUUU   miRNA  3'     U                    5'
Ortholog Group
Ortholog Groups: OG5_126781	Accession Taxon NP_001030990 Arabidopsis thaliana NP_001031017 Arabidopsis thaliana NP_001117210 Arabidopsis thaliana NP_172492 Arabidopsis thaliana NP_179409 Arabidopsis thaliana NP_181907 ( AT2G43790 ) Arabidopsis thaliana NP_190150 Arabidopsis thaliana NP_191538 Arabidopsis thaliana NP_192046 Arabidopsis thaliana NP_195363 Arabidopsis thaliana NP_564746 Arabidopsis thaliana NP_567378 Arabidopsis thaliana NP_974049 Arabidopsis thaliana CMS295C Cyanidioschyzon merolae strain 10D 183031 Chlamydomonas reinhardtii 193901 Chlamydomonas reinhardtii 78072 Chlamydomonas reinhardtii ACO62312 Micromonas sp. RCC299 ACO64957 Micromonas sp. RCC299 NP_001045889 Oryza sativa Japonica Group NP_001049770 Oryza sativa Japonica Group NP_001056846 Oryza sativa Japonica Group NP_001058471 Oryza sativa Japonica Group NP_001061028 Oryza sativa Japonica Group NP_001065156 Oryza sativa Japonica Group e_gw1.09.00.214.1 Ostreococcus tauri e_gw1.59.77.1 Physcomitrella patens subsp. patens estExt_fgenesh1_pg.C_1380074 Physcomitrella patens subsp. patens estExt_gwp_gw1.C_2070056 Physcomitrella patens subsp. patens 28752.m000329 Ricinus communis 29634.m002077 Ricinus communis 29747.m001048 Ricinus communis 30170.m013789 Ricinus communis 30174.m008647 Ricinus communis 30190.m011265 Ricinus communis fgenesh1_pg.C_chr_5000060 Thalassiosira pseudonana CCMP1335 XP_002948304 Volvox carteri f. nagariensis XP_002955338 Volvox carteri f. nagariensis
Cross Link
Database Entry ID E-value Start End InterPro ID Description PANTHER PTHR24055 4.1E-184 45 395 No hit NA ProSiteProfiles PS50011 45.6 63 348 IPR000719 Protein kinase, catalytic domain SMART SM00220 4.7E-98 63 348 IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain Pfam PF00069 1.5E-74 68 348 IPR000719 Protein kinase, catalytic domain SUPERFAMILY SSF56112 3.1E-98 68 356 IPR011009 Protein kinase-like domain ProSitePatterns PS00107 NA 69 93 IPR017441 Protein kinase, ATP binding site ProSitePatterns PS01351 NA 98 201 IPR003527 Mitogen-activated protein (MAP) kinase, conserved site ProSitePatterns PS00108 NA 185 197 IPR008271 Serine/threonine-protein kinase, active site
Subcellular Localization
Localization	cytosol
Evidence	SUBAcon
Pubmed ID	23180787