Basic information
Locus name	AT3G17810
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Nucleic acid degradation
Effect for Senescence	unclear
Gene Description	dihydroorotate dehydrogenase family protein / dihydroorotate oxidase family protein low similarity to SP|Q12882 Dihydropyrimidine dehydrogenase [NADP+] precursor (EC 1.3.1.2) (DPD) (DHPDHase) (Dihydrouracil dehydrogenase) (Dihydrothymine dehydrogenase) {Homo sapiens}; contains Pfam profile PF01180: Dihydroorotate dehydrogenase
Evidence	Genomic evidence:microarray data [Ref 1]
References	1: Buchanan-Wollaston V, Page T, Harrison E, Breeze E, Lim PO, Nam HG, Lin JF, Wu SH, Swidzinski J, Ishizaki K, Leaver CJ Comparative transcriptome analysis reveals significant differences in gene expression and signalling pathways between developmental and dark/starvation-induced senescence in Arabidopsis. Plant J. 2005 May;42(4):567-85
Gene Ontology	biological process UMP biosynthetic process oxidation-reduction process molecular function dihydroorotate dehydrogenase activity
Pathway	Reactome REACT_1698 KEGG map00240 (EC 1.3.3.1)
Sequence	AT3G17810.1 | Genomic | mRNA | CDS | Protein
Microarray
Sampling	Buchanan-Wollaston V, Page T, Harrison E, Breeze E, Lim PO, Nam HG, Lin JF, Wu SH, Swidzinski J, Ishizaki K, Leaver CJ. Comparative transcriptome analysis reveals significant differences in gene expression and signalling pathways between developmental and dark/starvation-induced senescence in Arabidopsis. Plant J. 2005 May;42(4)
Comparation	Legends: Col: wild type, indicates the ratio of expression in senescing leaves/green leaves. NahG, coi1 and ein2: indicates the ratio of expression in senescing leaves of mutant/senescing wild type. D/L: ratio of DARK 5d/control. CD: Cell Death, ratio of starved cell suspension culture/control. Genes showing at least 3 fold (ratio) up regulation during leaf senescence.
miRNA Interaction
Details	target: AT3G17810.1  miRNA: ath-miR170 miRNA: ath-miR170 mfe: -24.2 kcal/mol  p-value: 0.047906  position:  1209  target 5' U    A          A      U 3'             GAUG UG CACGGCU UGGUCA              CUAU AC GUGCCGA GUUAGU   miRNA  3'      A  U                5'  target: AT3G17810.1  miRNA: ath-miR835-3p miRNA: ath-miR835-3p mfe: -28.0 kcal/mol  p-value: 0.001558  position:  84  target 5' A    G         G     U 3'             CUUU UUGCGUGUC UCUUC              GAAA AACGCAUAG AGAGG   miRNA  3'      G         A     U 5'  target: AT3G17810.1  miRNA: ath-miR846 miRNA: ath-miR846 mfe: -20.7 kcal/mol  p-value: 0.079901  position:  1507  target 5' A         A           C 3'             GGUUC AGC ACUUCA UUCA              UUAAG UCG UGAAGU AAGU   miRNA  3'       U          U    U 5'
Ortholog Group
Ortholog Groups: OG5_129390	Accession Taxon NP_188408 ( AT3G17810 ) Arabidopsis thaliana 134846 Chlamydomonas reinhardtii ACO67372 Micromonas sp. RCC299 NP_001048053 Oryza sativa Japonica Group e_gw1.294.45.1 Physcomitrella patens subsp. patens fgenesh1_pg.scaffold_40000044 Physcomitrella patens subsp. patens 27791.m000086 Ricinus communis XP_002948755 Volvox carteri f. nagariensis
Cross Link
Database Entry ID E-value Start End InterPro ID Description PIRSF PIRSF000164 5.0E-86 3 379 IPR012135 Dihydroorotate dehydrogenase, class 1/ 2 SUPERFAMILY SSF51395 3.7E-71 44 378 No hit NA PANTHER PTHR11938 2.0E-293 47 426 No hit NA Pfam PF01180 1.9E-33 52 362 IPR012135 Dihydroorotate dehydrogenase, class 1/ 2 TIGRFAM TIGR01037 2.0E-51 52 376 IPR005720 Dihydroorotate dehydrogenase domain
Subcellular Localization
Localization	plastid
Evidence	SUBAcon
Pubmed ID	23180787