Basic information
Locus name	AT2G39770
Alias	VTC1/CYT1/SOZ1/GMP1/EMB101
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Lipid/Carbohydrate metabolism:vitamin C
Effect for Senescence	delay
Gene Description	Encodes a GDP-mannose pyrophosphorylase/ mannose-1-pyrophosphatase. This enzyme provides GDP-mannose, which is used for cell wall carbohydrate biosynthesis and protein glycosylation as well as for ascorbate (vitamin C) biosynthesis. Mutations in this gene confer hypersensitivity to NH4+.
Evidence	Genetic evidence:Mutant [Ref 1]
References	1: Barth C, Moeder W, Klessig DF, Conklin PL The timing of senescence and response to pathogens is altered in the ascorbate-deficient Arabidopsis mutant vitamin c-1. Plant Physiol. 200 Apr;134(4):1784-92
Gene Ontology	biological process biosynthetic process molecular function nucleotidyltransferase activity
Pathway	Reactome REACT_17015
Sequence	AT2G39770.1 | Genomic | mRNA | CDS | Protein
Mutant information
Mutant name	vtc1
Mutant/Transgenic	mutant
Ecotype	Col-0
Mutagenesis type	EMS
Ortholog Group
Ortholog Groups: OG5_127109	Accession Taxon NP_181507 ( AT2G39770 ) Arabidopsis thaliana NP_191118 Arabidopsis thaliana NP_194786 Arabidopsis thaliana CML145C Cyanidioschyzon merolae strain 10D 130417 Chlamydomonas reinhardtii NP_001044795 Oryza sativa Japonica Group NP_001049673 Oryza sativa Japonica Group NP_001061320 Oryza sativa Japonica Group estExt_Genewise1.C_1140222 Physcomitrella patens subsp. patens estExt_gwp_gw1.C_3230009 Physcomitrella patens subsp. patens 30143.m001191 Ricinus communis XP_002952855 Volvox carteri f. nagariensis
Cross Link
Database Entry ID E-value Start End InterPro ID Description PANTHER PTHR22572 1.2E-172 1 361 No hit NA SUPERFAMILY SSF53448 1.3E-71 1 312 No hit NA Pfam PF00483 9.7E-48 2 228 IPR005835 Nucleotidyl transferase Pfam PF00132 1.5E-6 261 294 IPR001451 Bacterial transferase hexapeptide repeat
Subcellular Localization
Localization	cytosol
Evidence	SUBAcon
Pubmed ID	23180787