Basic information
Locus name	AT5G63110
Alias	HDA6
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Hormone response pathway:JA
Effect for Senescence	promote
Gene Description	RPD3-like histone deacetylase. HDA6 mutations specifically increase the expression of auxin-responsive transgenes, suggesting a role in transgene silencing.HDA6-RNAi plants displayed increased leaf longevity compared with the wild type. The expression of the senescence-associated genes, SAG12 and SEN4, was down-regulated in HDA6-RNAi plants. In addition,HDA6-RNAi plants displayed late-flowering.
Evidence	Genetic evidence:Transgene [Ref 1]
References	1: Wu K, Zhang L, Zhou C, Yu CW, Chaikam V HDA6 is required for jasmonate response, senescence and flowering in Arabidopsis. J. Exp. Bot. 2008;59(2):225-34
Gene Ontology	biological process histone deacetylation molecular function histone deacetylase activity
Sequence	AT5G63110.1 | Genomic | mRNA | CDS | Protein
Mutant information
Mutant name	HAD6_RNAi
Mutant/Transgenic	transgenic
Ecotype	Col-0
Mutagenesis type	RNAi
miRNA Interaction
Details	target: AT5G63110.1  miRNA: ath-miR869 miRNA: ath-miR869 mfe: -24.5 kcal/mol  p-value: 0.046145  position:  1156  target 5' U    G               U 3'             UUGA UAUUUCGGC CCAGA              AGUU AUAGAGUUG GGUCU   miRNA  3' C    G         U       5'
Ortholog Group
Ortholog Groups: OG5_126742	Accession Taxon NP_001078511 Arabidopsis thaliana NP_190054 Arabidopsis thaliana NP_195526 Arabidopsis thaliana NP_201116 ( AT5G63110 ) Arabidopsis thaliana CMJ129C Cyanidioschyzon merolae strain 10D CMS068C Cyanidioschyzon merolae strain 10D 103457 Chlamydomonas reinhardtii 137868 Chlamydomonas reinhardtii NP_113378 Guillardia theta ACO61760 Micromonas sp. RCC299 ACO65466 Micromonas sp. RCC299 NP_001046284 Oryza sativa Japonica Group NP_001046287 Oryza sativa Japonica Group NP_001057943 Oryza sativa Japonica Group NP_001061596 Oryza sativa Japonica Group NP_001067440 Oryza sativa Japonica Group estExt_gwp_GeneWisePlus.C_Chr_02.00010172 Ostreococcus tauri gw1.02.00.256.1 Ostreococcus tauri e_gw1.223.109.1 Physcomitrella patens subsp. patens estExt_fgenesh1_pg.C_1800041 Physcomitrella patens subsp. patens estExt_gwp_gw1.C_3510032 Physcomitrella patens subsp. patens 29659.m000144 Ricinus communis 29791.m000547 Ricinus communis 30147.m013886 Ricinus communis e_gw1.2.174.1 Thalassiosira pseudonana CCMP1335 estExt_gwp_gw1.C_chr_60262 Thalassiosira pseudonana CCMP1335 XP_002952849 Volvox carteri f. nagariensis XP_002955640 Volvox carteri f. nagariensis
Cross Link
Database Entry ID E-value Start End InterPro ID Description PANTHER PTHR10625 1.9E-279 17 461 IPR000286 Histone deacetylase superfamily PIRSF PIRSF037913 9.4E-292 17 468 IPR003084 Histone deacetylase SUPERFAMILY SSF52768 3.6E-125 19 383 No hit NA Pfam PF00850 2.2E-88 35 330 IPR023801 Histone deacetylase domain PRINTS PR01271 5.2E-60 40 57 IPR003084 Histone deacetylase PRINTS PR01271 5.2E-60 73 91 IPR003084 Histone deacetylase PRINTS PR01271 5.2E-60 106 123 IPR003084 Histone deacetylase PRINTS PR01271 5.2E-60 127 147 IPR003084 Histone deacetylase PRINTS PR01270 2.6E-24 149 172 IPR000286 Histone deacetylase superfamily PRINTS PR01271 5.2E-60 168 184 IPR003084 Histone deacetylase PRINTS PR01270 2.6E-24 181 196 IPR000286 Histone deacetylase superfamily PRINTS PR01271 5.2E-60 227 240 IPR003084 Histone deacetylase PRINTS PR01271 5.2E-60 244 262 IPR003084 Histone deacetylase PRINTS PR01270 2.6E-24 266 276 IPR000286 Histone deacetylase superfamily
Mutant Image
hda6 (CS66153) mutant exhibited delay senescence phenotype compared with wild type Col-0 (7-week-old).
Subcellular Localization
Localization	nucleus
Evidence	SUBAcon
Pubmed ID	23180787