Basic information
Locus name	AT4G29380
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Protein degradation/modification:protein kinase and phosphatases
Effect for Senescence	unclear
Gene Description	protein kinase family protein / WD-40 repeat family protein contains Pfam PF00400: WD domain, G-beta repeat; contains Pfam PF00069: Protein kinase domain; contains PF02985: HEAT repeat; similar to adaptor protein (GI:1817584) [Homo sapiens]; similar to VPS15 protein (GI:6103009) [Pichia pastoris]
Evidence	Genomic evidence:microarray data [Ref 1]
References	1: Buchanan-Wollaston V, Page T, Harrison E, Breeze E, Lim PO, Nam HG, Lin JF, Wu SH, Swidzinski J, Ishizaki K, Leaver CJ Comparative transcriptome analysis reveals significant differences in gene expression and signalling pathways between developmental and dark/starvation-induced senescence in Arabidopsis. Plant J. 2005 May;42(4):567-85
Gene Ontology	biological process protein phosphorylation molecular function ATP binding protein binding protein kinase activity protein serine/threonine kinase activity
Sequence	AT4G29380.1 | Genomic | mRNA | CDS | Protein
Microarray
Sampling	Buchanan-Wollaston V, Page T, Harrison E, Breeze E, Lim PO, Nam HG, Lin JF, Wu SH, Swidzinski J, Ishizaki K, Leaver CJ. Comparative transcriptome analysis reveals significant differences in gene expression and signalling pathways between developmental and dark/starvation-induced senescence in Arabidopsis. Plant J. 2005 May;42(4)
Comparation	Legends: Col: wild type, indicates the ratio of expression in senescing leaves/green leaves. NahG, coi1 and ein2: indicates the ratio of expression in senescing leaves of mutant/senescing wild type. D/L: ratio of DARK 5d/control. CD: Cell Death, ratio of starved cell suspension culture/control. Genes showing at least 3 fold (ratio) up regulation during leaf senescence.
miRNA Interaction
Details	target: AT4G29380.1  miRNA: ath-miR397b miRNA: ath-miR397b mfe: -24.9 kcal/mol  p-value: 0.068577  position:  1494  target 5' A    U          G C    A 3'             AUCG GCGGUGCGCU C AUGG              UAGU UGCUACGUGA G UACU   miRNA  3' G                 U      5'
Ortholog Group
Ortholog Groups: OG5_129368	Accession Taxon NP_194667 ( AT4G29380 ) Arabidopsis thaliana 174860 Chlamydomonas reinhardtii ACO61132 Micromonas sp. RCC299 NP_001048391 Oryza sativa Japonica Group 0300010407 Ostreococcus tauri e_gw1.213.1.1 Physcomitrella patens subsp. patens estExt_fgenesh2_pm.C_990017 Physcomitrella patens subsp. patens 29912.m005424 Ricinus communis fgenesh1_pg.C_chr_3000868 Thalassiosira pseudonana CCMP1335 XP_002947818 Volvox carteri f. nagariensis
Cross Link
Database Entry ID E-value Start End InterPro ID Description PANTHER PTHR17583 0.0 2 1494 No hit NA SUPERFAMILY SSF56112 1.4E-41 26 292 IPR011009 Protein kinase-like domain ProSiteProfiles PS50011 23.3 27 307 IPR000719 Protein kinase, catalytic domain SMART SM00220 4.4E-14 27 295 IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain Pfam PF00069 5.7E-26 29 293 IPR000719 Protein kinase, catalytic domain ProSitePatterns PS00108 NA 145 157 IPR008271 Serine/threonine-protein kinase, active site SUPERFAMILY SSF48371 3.1E-39 281 566 IPR016024 Armadillo-type fold Pfam PF02985 5.8E-4 485 513 IPR000357 HEAT ProSiteProfiles PS50077 9.1 485 517 IPR021133 HEAT, type 2 SUPERFAMILY SSF48371 3.1E-39 596 844 IPR016024 Armadillo-type fold Coils Coil NA 598 619 No hit NA ProSiteProfiles PS50077 9.1 653 691 IPR021133 HEAT, type 2 SMART SM00320 1.1E-8 1070 1109 IPR001680 WD40 repeat Pfam PF00400 1.9E-8 1072 1109 IPR001680 WD40 repeat SUPERFAMILY SSF50978 2.1E-34 1074 1352 IPR017986 WD40-repeat-containing domain ProSiteProfiles PS50082 14.5 1077 1109 IPR001680 WD40 repeat ProSiteProfiles PS50294 14.2 1077 1270 IPR017986 WD40-repeat-containing domain SMART SM00320 14.0 1120 1157 IPR001680 WD40 repeat SMART SM00320 0.1 1220 1261 IPR001680 WD40 repeat ProSiteProfiles PS50082 8.9 1229 1263 IPR001680 WD40 repeat SMART SM00320 140.0 1366 1400 IPR001680 WD40 repeat SUPERFAMILY SSF50978 2.1E-34 1384 1413 IPR017986 WD40-repeat-containing domain SMART SM00320 0.4 1454 1494 IPR001680 WD40 repeat ProSiteProfiles PS50082 10.1 1461 1494 IPR001680 WD40 repeat ProSiteProfiles PS50294 9.9 1461 1494 IPR017986 WD40-repeat-containing domain Pfam PF00400 0.0 1464 1494 IPR001680 WD40 repeat SUPERFAMILY SSF50978 2.1E-34 1464 1492 IPR017986 WD40-repeat-containing domain