Basic mutant information
Mutant name	CCS52A_RNAi
Mutant/Transgenic	transgenic
Ecotype	Medicago sativa
Mutagenesis type	RNAi
(Semi-)Dominant/Recessive	recessive
Description	early senescence
References	1: Vinardell JM, Fedorova E, Cebolla A, Kevei Z, Horvath G, Kelemen Z, Tarayre S, Roudier F, Mergaert P, Kondorosi A, Kondorosi E Endoreduplication mediated by the anaphase-promoting complex activator CCS52A is required for symbiotic cell differentiation in Medicago truncatula nodules. Plant Cell 2003 Sep;15(9):2093-105
Mutated genes
GenBank ID	AF134835
Alias	CCS52A
Organism	Alfalfa (Medicago sativa)
Description	The CCS52A protein was present in the nucleus of endoreduplication-competent cells, indicating that it may activate APC constitutively during the endoreduplication cycles. Downregulation of ccs52A in transgenic M. truncatula plants drastically affected nodule development, resulting in lower ploidy, reduced cell size, inefficient invasion, and the maturation of symbiotic cells, accompanied by early senescence and finally the death of both the bacterium and plant cells.
Phenotype information
Natural senescence Cell death marker:other yes