| Title |
The effects of antiphospholipid antibodies on THP-1 M0 macrophages in vitro. |
| Description |
We extracted IgG from the serum of six obstetric antiphospholipid syndrome patients to get aPL-IgG. Similarly, HC-IgG was obtained from the serum of six healthy controls. We used aPL-IgG/ recombined beta2 glycoprotein I (beta 2GPI) complex and HC-IgG/ beta 2GPI complex to stimulate THP-1 derived M0 macrophages for 48 hours. The total RNA of M0 macrophages with stimulation was extracted for mRNA sequencing in the DNBSEQ-T7 platform. "A" represents aPL-IgG/ beta 2GPI group, "H" represents HC-IgG/ beta 2GPI group. There were 3 biological replicates in each group. |
| Organism |
Homo sapiens |
| Data Type |
Expression Profiling by NGS |
| Data Accessibility |
Controlled-access |
| BioProject |
PRJCA034881 |
| Release Date |
2025-06-01 |
| Submitter |
Rui Gao (kaojui@yeah.net) |
| Organization |
West China Second University Hospital |
| Submission Date |
2025-01-10 |