| Title | The effects of antiphospholipid antibodies on THP-1 M0 macrophages in vitro. |
|---|---|
| Description | We extracted IgG from the serum of six obstetric antiphospholipid syndrome patients to get aPL-IgG. Similarly, HC-IgG was obtained from the serum of six healthy controls. We used aPL-IgG/ recombined beta2 glycoprotein I (beta 2GPI) complex and HC-IgG/ beta 2GPI complex to stimulate THP-1 derived M0 macrophages for 48 hours. The total RNA of M0 macrophages with stimulation was extracted for mRNA sequencing in the DNBSEQ-T7 platform. "A" represents aPL-IgG/ beta 2GPI group, "H" represents HC-IgG/ beta 2GPI group. There were 3 biological replicates in each group. |
| Organism | Homo sapiens |
| Data Type | Expression Profiling |
| Data Accessibility | Controlled-access |
| BioProject | PRJCA034881 |
| Release Date | 2025-06-01 |
| Submitter | Rui Gao (kaojui@yeah.net) |
| Organization | West China Second University Hospital |
| Submission Date | 2025-01-10 |
The data cannot be downloaded as it has not yet been registered in the Human Genetic Resource Management Platform of MOST.
| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download |
|---|---|---|---|---|---|---|
| OMIX008642-01 | Quantificational_Data | 1 | Expression Profiling | 3.2 MB | zip | Unavailable |
| Paper Title | Journal Name | Publish Time | Accession | Citing Type |
|---|---|---|---|---|
| Deciphering the Role and Mechanism of Decidual Monocyte‐Derived Macrophage Infiltration in Obstetric Antiphospholipid Syndrome at Single‐Cell Resolution | Advanced Science | 2025-08 | OMIX008643 OMIX008641 OMIX008642 | Deposit |