DOT4 - Plant Editosome Database - CNCB-NGDC

DOT4 - Plant Editosome Database - CNCB-NGDC

Summary

Editing Factor:	DOT4
Synonym:	DEFECTIVELY ORGANIZED TRIBUTARIES 4
Description:	DOT4 has DYW deaminase domains and are required for single RNA editing events in chloroplasts
Protein Family:	Pentatricopeptide repeat (PPR) protein
Subclass:	DYW
Physical Interaction:	NA
Construct Structure:	PLS-E-E+-DYW
Gene ID & Species:	AT4G18750 (Arabidopsis thaliana)
Edited Gene(s):	rpoC1
Editing Type(s):	C-to-U (3)
Publication(s):	[1] Identification of Two Pentatricopeptide Repeat Genes Required for RNA Editing and Zinc Binding by C-terminal Cytidine Deaminase-like Domains, The Journal of Biological Chemistry, 2013. [doi:10.1074/jbc.M113.485755]

Editing Details

Species

Gene ID

Organelle

Edited Gene

Position

Region

Nuclear Genome

Organelle Genome

Other Region

Other Position

Editing Type

Codon

Amino Acid

Molecular Effect

Experiment Details

Arabidopsis thaliana

AT4G18750

Chloroplast

488

CDS

NA

NA

NA

NA

C-to-U

UCA=>UUA

S=>L

Recoding

**Experiment Details**
Genotype (Ecotype)	Allele	Treatment	Treatment Detail	Mutant Type	Phenotype	Tissue	Development Stage	Detection Method	Editing Frequency	Editing Extent	Mutant Effect	PMID
SALK_139995	dot4-2	T-DNA Insertion	T-DNA is inserted in repeat 5	knockout	A striking phenotype of serrated white to pale green leaves, and the formation of radially symmetric, needle-shaped leaves	NA	NA	Bulk sequencing	NA	Unedited	Absent	24194514
CS3254	flv	Point Mutation	Point mutant at Gly-554 (GGA to TGA) creates a stop codon in repeat 11	NA	A striking phenotype of serrated white to pale green leaves, and the formation of radially symmetric, needle-shaped leaves	NA	NA	Bulk sequencing	NA	Unedited	Absent	24194514
Col-0	WT	Control	Control	No mutant	Normal	NA	NA	Bulk sequencing	NA	Medium	None	24194514

Last update: Sep 2026 (version 2.0)