Plant
Editosome
Database
Summary
| Editing Factor: | ISE2 |
| Synonym: | 115J-4A; EMB25; EMBRYO DEFECTIVE 25; INCREASED SIZE EXCLUSION LIMIT 2; PDE317; PIGMENT DEFECTIVE 317 |
| Description: | Loss of ISE2 from Arabidopsis thaliana leaves resulted in defects in C-to-U RNA editing, altered accumulation of chloroplast transcripts and chloroplast-encoded proteins, and defective processing of chloroplast ribosomal RNAs; Potential ISE2 substrates were identified by RNA immunoprecipitation followed by next-generation sequencing (RIP-seq), and the diversity of RNA species identified supports ISE2's involvement in multiple aspects of chloroplast RNA metabolism; Comprehensive phylogenetic analyses revealed that ISE2 is a non-canonical Ski2-like RNA helicase that represents a separate sub-clade unique to green photosynthetic organisms, consistent with its function as an essential protein |
| Protein Family: | DEVH-box RNA helicase |
| Subclass: | NA |
| Physical Interaction: | IPI1 |
| Construct Structure: | NA |
| Gene ID & Species: | NA (Nicotiana benthamiana) |
| Edited Gene(s): | ndhD rpoB |
| Editing Type(s): | C-to-U (4) |
| Publication(s): |
[1] The dicot homolog of maize PPR103 carries a C-terminal DYW domain and is required for C-to-U editing of chloroplast RNA transcripts, Research Square, 2023. [doi:10.21203/rs.3.rs-2574001/v1] |
Editing Details
| Species | Gene ID | Organelle | Edited Gene | Position | Region | Nuclear Genome | Organelle Genome | Other Region | Other Position | Editing Type | Codon | Amino Acid | Molecular Effect | Experiment Details | |||||||||||||||||||||||||||||||||||||
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| Nicotiana benthamiana | NA | Chloroplast | ndhD | NA | NA | http://benthgenome.qut.edu.au | http://benthgenome.qut.edu.au | NA | NA | C-to-U | NA=>NA | NA=>NA | NA |
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| Nicotiana benthamiana | NA | Chloroplast | rpoB | NA | NA | http://benthgenome.qut.edu.au | http://benthgenome.qut.edu.au | NA | NA | C-to-U | NA=>NA | NA=>NA | NA |
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Last update: Sep 2026
(version 2.0)