LOI1 - Plant Editosome Database - BIG Data Center

Summary

Editing Factor: LOI1
Synonym: LOI1, LOVASTATIN INSENSITIVE 1, MEF11, MITOCHONDRIAL RNA EDITING FACTOR 11
Description: Encodes a pentatricopeptide (PPR) protein that binds single-stranded RNA. The N-terminal portion of the protein can localize to the mitochondria. Mutations in this gene make plants less sensitive to inhibitors of the MEP and MVA pathways of isoprenoid biosynthesis and increase the activity of HMG CoA reductase
Protein Family: PPR
Subclass: NA
Construct Structure: NA
Gene ID & Species: At4g14850 (Arabidopsis thaliana)
Edited Gene(s): NA
Editing Type(s): NA (4)
Publication(s): [1] Lovastatin insensitive 1, a Novel pentatricopeptide repeat protein, is a potential regulatory factor of isoprenoid biosynthesis in Arabidopsis, Plant Cell Physiol, 2007. [PMID=17213228]

Editing Details

Species Gene ID Organelle Edited Gene Position Region Editing Type Codon Amino Acid Molecular Effect Experiment Details
Arabidopsis thaliana At4g14850 Mitochondrion NA null NA NA NA=>NA NA=>NA NA
Experiment Details
Genotype (Ecotype) Allele Treatment Treatment Detail Mutant Type Phenotype Tissue Development Stage Detection Method Editing Frequency Editing Extent Mutant Effect PMID
Col-0WTNo treatment No treatmentNo treatmentRoot elongation in WT plants grown with 300 nM lovastatin was strongly reducedRootNANANANANA17213228
Col-0loi1-1T-DNA insertionA T-DNA insertion was at +542bp in the first exon of the At4g14850 geneHomozygousThe root elongation of treated loi1-1 plants was less affectedRootNANANANANA17213228
Col-0loi1-2T-DNA insertionA T-DNA insertion was at +729bp in the first exon of the At4g14850 geneNAThe root elongation of treated loi1-2 plants was less affectedRootNANANANANA17213228
Col-035S:: LOI1 in loi1-1T-DNA insertionA T-DNA insertion was at +542bp in the first exon of the At4g14850 gene. A DNA fragment containing the first 39 amino acid residues of the LOI1 protein and five residues of the glycine linker was ampHomozygousRoot elongation in loi1-1(35S:: LOI1) plants grown with 300 nM lovastatin was strongly reducedRootNANANANANA17213228
Last update: Jul 2021 (version 1.0)