| Editing Factor: |
LOI1 |
| Synonym: |
LOVASTATIN INSENSITIVE 1; MEF11; MITOCHONDRIAL RNA EDITING FACTOR 11 |
| Description: |
As a result of analysis of RNA editing of mitochondrial genes in loi1, a defect in RNA editing of three genes, nad4, ccb203 and cox3, was identified in loi1; Wild type (WT) treated with some respiration inhibitors mimicked the loi1 phenotype; HMG-CoA reductase activity of WT treated with lovastatin combined with antimycin A, an inhibitor of complex III in the respiratory chain, was higher than that of WT treated with only lovastatin, despite the lack of alteration of transcript or protein levels of HMGR; These results suggest that HMGR enzyme activity is regulated through the respiratory cytochrome pathway; LOI1 is predicted to localize in mitochondria and has the ability to bind single-stranded nucleic acids; The post-transcriptional regulation of mitochondrial RNA may be involved in isoprenoid biosynthesis in both the MVA and MEP pathways |
| Protein Family: |
Pentatricopeptide repeat (PPR) protein
|
| Subclass: |
DYW
|
| Physical Interaction: |
NA
|
| Construct Structure: |
PLS-E-DYW
|
| Gene ID & Species: |
AT4G14850 (Arabidopsis thaliana)
|
| Edited Gene(s): |
nad4 ccmFn2 cox3 NA
|
| Editing Type(s): |
C-to-U (9) NA (4)
|
| Publication(s): |
[1] The mitochondrial PPR protein LOVASTATIN INSENSITIVE 1 plays regulatory roles in cytosolic and plastidial isoprenoid biosynthesis through RNA editing, The Plant Journal, 2010. [doi:10.1111/j.1365-313X.2009.04082.x]
[2] Lovastatin insensitive 1, a Novel pentatricopeptide repeat protein, is a potential regulatory factor of isoprenoid biosynthesis in Arabidopsis, Plant Cell Physiol, 2007. [doi:10.1093/pcp/pcm005]
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