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eQTL Dataset Sample Size

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Cell Type Distribution

Number of Associated Traits

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Cell Type	Tissues	#Assocaited Genes	Associated Traits	eQTL Datasets
Astrocyte	Brain	52	Depression	Zeng et al. 2023 Biol Psychiatry
B cell	PBMC	11955	Psoriasis, Prostate Cancer, Endometrial Cancer, Asthma, Heart Failure, Glaucoma, Type 1 Diabetes Mellitus, COVID-19, Oral Cavity and Pharyngeal Cancer, Systemic Lupus Erythematosus, Anemia, Pancreas Disease, Epilepsy, Arthritis, Alzheimer's Disease, Eczema, Low Density Lipoprotein Cholesterol Measurement, Multiple Sclerosis, Rheumatoid Arthritis, High Density Lipoprotein Cholesterol Measurement, Major Depressive Disorder, Type 2 Diabetes Mellitus, Crohn's Disease, Primary Biliary Cirrhosis, Sarcoidosis, Irritable Bowel Syndrome, Sjogren's Syndrome, Fasting Blood Glucose Measurement, Coronary Artery Disease, Bipolar Disorder, Ulcerative Colitis, Chronic Kidney Disease	Wiljs et al. 2018 Nat Genet; Randolph et al. 2021 Science; Oelen et al. 2022 Nat Commun; Perez et al. 2022 Science; Yin et al. 2022 Ann Rheum Dis; Aquino et al. 2023 Nature; Resztak et al. 2023 Genome Res
CD14-positive monocyte	PBMC	2107	Psoriasis, Prostate Cancer, Endometrial Cancer, Asthma, Heart Failure, Glaucoma, Type 1 Diabetes Mellitus, COVID-19, Alzheimer's Disease, Systemic Lupus Erythematosus, Anemia	Kang et al. 2017 Nat Biotechnol
CD4-positive T cell	PBMC	12990	Psoriasis, Prostate Cancer, Endometrial Cancer, Asthma, Heart Failure, Glaucoma, Type 1 Diabetes Mellitus, COVID-19, Oral Cavity and Pharyngeal Cancer, Alzheimer's Disease, Systemic Lupus Erythematosus, Anemia, Pancreas Disease, Epilepsy, Arthritis, Type 2 Diabetes Mellitus, High Density Lipoprotein Cholesterol Measurement, Rheumatoid Arthritis, Multiple Sclerosis, Primary Biliary Cirrhosis, Irritable Bowel Syndrome, Sarcoidosis, Major Depressive Disorder, Low Density Lipoprotein Cholesterol Measurement, Bipolar Disorder, Sjogren's Syndrome, Ulcerative Colitis, Eczema, Crohn's Disease, Coronary Artery Disease, Chronic Kidney Disease, Fasting Blood Glucose Measurement	Kang et al. 2017 Nat Biotechnol; Wiljs et al. 2018 Nat Genet; Randolph et al. 2021 Science; Nathan et al. 2022 Nature; Oelen et al. 2022 Nat Commun; Perez et al. 2022 Science; Schmiedel et al. 2022 Sci Immunol; Yin et al. 2022 Ann Rheum Dis; Aquino et al. 2023 Nature
CD8-positive T cell	PBMC	12715	Psoriasis, Prostate Cancer, Endometrial Cancer, Asthma, Heart Failure, Glaucoma, Type 1 Diabetes Mellitus, COVID-19, Oral Cavity and Pharyngeal Cancer, Alzheimer's Disease, Systemic Lupus Erythematosus, Anemia, Epilepsy, Arthritis, Low Density Lipoprotein Cholesterol Measurement, Fasting Blood Glucose Measurement, High Density Lipoprotein Cholesterol Measurement, Crohn's Disease, Multiple Sclerosis, Rheumatoid Arthritis, Type 2 Diabetes Mellitus, Primary Biliary Cirrhosis, Major Depressive Disorder, Sarcoidosis, Irritable Bowel Syndrome, Sjogren's Syndrome, Bipolar Disorder, Eczema, Ulcerative Colitis, Coronary Artery Disease, Chronic Kidney Disease	Kang et al. 2017 Nat Biotechnol; Wiljs et al. 2018 Nat Genet; Randolph et al. 2021 Science; Nathan et al. 2022 Nature; Oelen et al. 2022 Nat Commun; Perez et al. 2022 Science; Yin et al. 2022 Ann Rheum Dis; Aquino et al. 2023 Nature; Yin et al. 2022 Ann Rheum Dis
Classical monocyte	PBMC	1783	Psoriasis, Prostate Cancer, Endometrial Cancer, Asthma, Heart Failure, Glaucoma, Type 1 Diabetes Mellitus, COVID-19, Oral Cavity and Pharyngeal Cancer, Alzheimer's Disease, Systemic Lupus Erythematosus, Anemia, Epilepsy, Low Density Lipoprotein Cholesterol Measurement, Primary Biliary Cirrhosis, Type 2 Diabetes Mellitus, Fasting Blood Glucose Measurement, High Density Lipoprotein Cholesterol Measurement, Rheumatoid Arthritis, Irritable Bowel Syndrome, Multiple Sclerosis, Bipolar Disorder, Major Depressive Disorder, Sjogren's Syndrome, Coronary Artery Disease, Ulcerative Colitis, Crohn's Disease, Chronic Kidney Disease, Sarcoidosis, Eczema	Thompson et al. 2022 Nat Commun
Conventional dendritic cell	PBMC	1047	Psoriasis, Prostate Cancer, Endometrial Cancer, Asthma, Heart Failure, Glaucoma, Type 1 Diabetes Mellitus, COVID-19, Oral Cavity and Pharyngeal Cancer, Systemic Lupus Erythematosus, Anemia, Low Density Lipoprotein Cholesterol Measurement, Primary Biliary Cirrhosis, Rheumatoid Arthritis, Type 2 Diabetes Mellitus, Crohn's Disease, Fasting Blood Glucose Measurement, High Density Lipoprotein Cholesterol Measurement, Irritable Bowel Syndrome, Multiple Sclerosis, Sarcoidosis, Sjogren's Syndrome, Major Depressive Disorder, Eczema, Ulcerative Colitis, Bipolar Disorder, Alzheimer's Disease, Coronary Artery Disease	Thompson et al. 2022 Nat Commun; Perez et al. 2022 Science
Dendritic cell	PBMC	11861	Psoriasis, Prostate Cancer, Endometrial Cancer, Asthma, Heart Failure, Glaucoma, Type 1 Diabetes Mellitus, COVID-19, Oral Cavity and Pharyngeal Cancer, Alzheimer's Disease, Systemic Lupus Erythematosus, Anemia, Pancreas Disease, Epilepsy, Arthritis, Type 2 Diabetes Mellitus, High Density Lipoprotein Cholesterol Measurement, Rheumatoid Arthritis, Multiple Sclerosis, Primary Biliary Cirrhosis, Irritable Bowel Syndrome, Sarcoidosis, Major Depressive Disorder, Low Density Lipoprotein Cholesterol Measurement, Bipolar Disorder, Sjogren's Syndrome, Ulcerative Colitis, Eczema, Crohn's Disease, Coronary Artery Disease, Chronic Kidney Disease, Fasting Blood Glucose Measurement	Kang et al. 2017 Nat Biotechnol; Wiljs et al. 2018 Nat Genet; Oelen et al. 2022 Nat Commun;
Endothelial cell	Brain	1	Depression	Zeng et al. 2023 Biol Psychiatry
Endothelial cell (alveolar capillary)	Lung	151	Psoriasis, Prostate Cancer, Endometrial Cancer, Asthma, Heart Failure, Glaucoma, Type 1 Diabetes Mellitus, COVID-19, Oral Cavity and Pharyngeal Cancer, Alzheimer's Disease, Systemic Lupus Erythematosus, Anemia	Natri et al. 2024 Nat Genet

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