| 项目编号 |
PRJCA008093 |
| 项目标题 |
Longitudinal circulating tumor DNA (ctDNA) profiling in metastatic colorectal cancer patients during anti-EGFR therapy |
| 涉及领域 |
Medical |
| 数据类型 |
Targeted Locus (Loci)
Raw sequence reads
|
| 物种名称 |
Homo sapiens
|
| 描述信息 |
Metastatic colorectal cancer (mCRC) is a heterogenous disease with limited precision medicine and targeted therapy options. Monoclonal antibodies against epidermal growth factor receptor (EGFR) have been a crucial treatment option for mCRC. However, proper biomarkers for predicting therapeutic response remain unknown. As a non-invasive test, circulating tumor DNA (ctDNA) is appropriately positioned to reveal tumor heterogeneity and evolution, as it can be used in real-time genomic profiling. To evaluate the significance of ctDNA in monitoring the dynamic therapeutic response and prognosis of mCRC, we detected the baseline and dynamic changes of ctDNA in mCRC patients receiving anti-EGFR therapies. |
| 样品范围 |
Multiisolate |
| 发布日期 |
2022-01-26 |
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| Shanghai Municipal Science and Technology Major Project
|
|
19411970800
|
|
| Shanghai Sailing Program
|
|
20YF1408900
|
|
|
|
| 提交者 |
Hao
Chen (hao.chen1@3dmedcare.com)
|
| 提交单位 |
3D Medicines Inc. |
| 提交日期 |
2022-01-26 |
