| Accession |
PRJCA010804 |
| Title |
NICHE-SKIRT (Systems Kinetics of Immune Reconstitution Tianjin) : Machine learning model was used to explore the effect of immune reconstitution on survival of patients after transplantation |
| Relevance |
Medical |
| Data types |
Clinical data
|
| Organisms |
Homo
|
| Description |
There is little consensus on how to quantitatively assess immune reconstitution after hematopoietic stem cell transplantation (HSCT) in real time as part of standard of care. We compiled 11150 post-transplant immune profiles of 1945 patients who underwent HSCT between 2012 and 2020 -termed the 'Systems Kinetics of Immune Reconstitution Tianjin' (SKIRT) dataset - with the median and 75th-percentile follow-up durations of 1.3 and 2.1 years, respectively, for immune profiling. We observed high levels of inter-personal variability, described the nonlinear dynamics of immune reconstitution, and characterized how the dynamics was jointly influenced by patient sex, patient age, stem cell source, transplant type, graft-versus-host disease, infection, donor age, and the donor's immune status. We also identified a high-risk immune signature that was predictive of earlier mortality and validated it in two independent sub-cohorts. A web tool, the 'SKIRT Calculator', was constructed to assist clinicians in evaluating the donor's immune status and the patient's progress in immune reconstitution. |
| Sample scope |
Not applicable |
| Release date |
2022-07-26 |
| Publication |
| PubMed ID |
Article title |
Journal name |
DOI |
Year |
| 36591789
|
The Composite Immune Risk Score predicts overall survival after allogeneic hematopoietic stem cell transplantation: A retrospective analysis of 1838 cases
|
American Journal of Hematology
|
10.1002/ajh.26792
|
2023
|
|
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| State Key Laboratory of Experimental Hematology
|
|
Z20-01
|
|
| National Natural Science Foundation of China (NSFC)
|
|
81470350
|
|
| the Fundamental Research Funds for the Central Universities
|
|
WK9110000001
|
|
|
|
| Submitter |
Xueou
Liu (liuxueou@ihcams.ac.cn)
|
| Organization |
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences |
| Submission date |
2022-02-17 |
