Accession |
PRJCA012642 |
Title |
Exploring the role of CD276 in bladder cancer progression by single-cell sequencing |
Relevance |
Medical |
Data types |
Single cell sequencing
|
Organisms |
Mus musculus
|
Description |
Immune checkpoint blockade (ICB) has revolutionized cancer immunotherapy. However, most cancer patients do not respond clinically, and therefore finding novel and effective immunotherapeutic approaches is warranted.Here, we found using a BBN induced bladder tumor model that CD276 -/- mice were more resistant to tumor growth than wild-type (WT) mice. Single cell results showed a drastic decrease of macrophages in the tumor. In response to this, we constructed myeloid cell conditional knockout mice and we found that CD276 knockdown reduced macrophage infiltration, diminished efferocytosis, enhanced antigen presentation and increased CD8 T cell infiltration. Furthermore, anti-CD276 mAb inhibited tumor growth and promoted regression when combined with anti-PD-1. Thus, CD276 may be targeted to modify tumor macrophage infiltration and enhance checkpoint immunotherapy |
Sample scope |
Single cell |
Release date |
2024-03-06 |
Publication |
PubMed ID |
Article title |
Journal name |
DOI |
Year |
38561369
|
CD276-dependent efferocytosis by tumor-associated macrophages promotes immune evasion in bladder cancer
|
Nature Communications
|
10.1038/s41467-024-46735-5
|
2024
|
|
Grants |
Agency |
program |
Grant ID |
Grant title |
National Natural Science Foundation of China (NSFC)
|
|
82173362
|
|
|
Submitter |
Demeng
Chen (chendm29@mail.sysu.edu.cn)
|
Organization |
First Affiliated Hospital of Sun Yat-sen University |
Submission date |
2022-10-20 |