e.g., PRJCA000229; PRJNA784038; human
Accession PRJCA012642
Title Exploring the role of CD276 in bladder cancer progression by single-cell sequencing
Relevance Medical
Data types Single cell sequencing
Organisms Mus musculus
Description Immune checkpoint blockade (ICB) has revolutionized cancer immunotherapy. However, most cancer patients do not respond clinically, and therefore finding novel and effective immunotherapeutic approaches is warranted.Here, we found using a BBN induced bladder tumor model that CD276 -/- mice were more resistant to tumor growth than wild-type (WT) mice. Single cell results showed a drastic decrease of macrophages in the tumor. In response to this, we constructed myeloid cell conditional knockout mice and we found that CD276 knockdown reduced macrophage infiltration, diminished efferocytosis, enhanced antigen presentation and increased CD8 T cell infiltration. Furthermore, anti-CD276 mAb inhibited tumor growth and promoted regression when combined with anti-PD-1. Thus, CD276 may be targeted to modify tumor macrophage infiltration and enhance checkpoint immunotherapy
Sample scope Single cell
Release date 2024-03-06
Publication
PubMed ID Article title Journal name DOI Year
38561369 CD276-dependent efferocytosis by tumor-associated macrophages promotes immune evasion in bladder cancer Nature Communications 10.1038/s41467-024-46735-5 2024
Grants
Agency program Grant ID Grant title
National Natural Science Foundation of China (NSFC) 82173362
Submitter Demeng Chen (chendm29@mail.sysu.edu.cn)
Organization First Affiliated Hospital of Sun Yat-sen University
Submission date 2022-10-20

Project Data

Resource name Description
BioSample (8)  show -
GSA (1) -
CRA008674 Exploring the role of CD276 in bladder cancer progression by single-cell sequencing