| 项目编号 |
PRJCA012642 |
| 项目标题 |
Exploring the role of CD276 in bladder cancer progression by single-cell sequencing |
| 涉及领域 |
Medical |
| 数据类型 |
Single cell sequencing
|
| 物种名称 |
Mus musculus
|
| 描述信息 |
Immune checkpoint blockade (ICB) has revolutionized cancer immunotherapy. However, most cancer patients do not respond clinically, and therefore finding novel and effective immunotherapeutic approaches is warranted.Here, we found using a BBN induced bladder tumor model that CD276 -/- mice were more resistant to tumor growth than wild-type (WT) mice. Single cell results showed a drastic decrease of macrophages in the tumor. In response to this, we constructed myeloid cell conditional knockout mice and we found that CD276 knockdown reduced macrophage infiltration, diminished efferocytosis, enhanced antigen presentation and increased CD8 T cell infiltration. Furthermore, anti-CD276 mAb inhibited tumor growth and promoted regression when combined with anti-PD-1. Thus, CD276 may be targeted to modify tumor macrophage infiltration and enhance checkpoint immunotherapy |
| 样品范围 |
Single cell |
| 发布日期 |
2024-03-06 |
| 出版信息 |
| PubMed ID |
文章标题 |
杂志名称 |
Doi |
发表年份 |
| 38561369
|
CD276-dependent efferocytosis by tumor-associated macrophages promotes immune evasion in bladder cancer
|
Nature Communications
|
10.1038/s41467-024-46735-5
|
2024
|
|
|
| 项目资金来源 |
| 机构 |
项目类型 |
授权项目ID |
授权项目名称 |
| National Natural Science Foundation of China (NSFC)
|
|
82173362
|
|
|
|
| 提交者 |
Demeng
Chen (chendm29@mail.sysu.edu.cn)
|
| 提交单位 |
First Affiliated Hospital of Sun Yat-sen University |
| 提交日期 |
2022-10-20 |
