| Accession |
PRJCA030332 |
| Title |
Integration of single-cell cis-eQTL mapping with GWAS for identifying cell type-specific susceptibility genes of colorectal cancer |
| Relevance |
Medical |
| Data types |
Phenotype or Genotype
Single cell sequencing
|
| Organisms |
Homo sapiens
|
| Description |
The associations between genetic variants and gene expression have been widely investigated in bulk-level tissues of colorectal cancer, but whether there was heterogeneity in diverse cell types remain unclear. Here, leveraging the genotyping and single-cell RNA sequencing data of 53 paired colorectal tumor-normal tissues, we applied expression quantitative trait loci (eQTL) analysis to identify an average of over 30,000 significant SNP-gene pairs across diverse cell types; noteworthily, most eQTL effects were specific to one cell type, and only less than 25% of them could be replicated in bulk-level eQTL. Totally, our findings demonstrated the cell-type specificity in genetic control of gene expression, which could advance the understanding of genetic mechanisms involved in colorectal cancer susceptibility. |
| Sample scope |
Multiisolate |
| Release date |
2024-09-25 |
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| National Natural Science Foundation of China (NSFC)
|
General Program
|
81822039
|
|
|
|
| Submitter |
Junyi
Xin (junyixin@njmu.edu.cn)
|
| Organization |
Nanjing Medical University |
| Submission date |
2024-09-19 |
