The dataset included a total of 1883 cells, the parameters adopted were as follows: resolution=1, PCs=1:20, MT<10%.

Receptor genes and their paired ligand genes were collected from CelltalkDB, SingleCellSingalR, Cellinker, Cell-Cell Interaction Database and Armingol E, et al., 2021. The following figures only demonstrated the expression of receptor genes and ligand genes supported by three or more databases or other sources, and the corresponding relationship between ligands and receptors were shown in the following table.

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Ligand	Receptor	Ligand	Receptor	Ligand	Receptor	Ligand	Receptor
ADAM10	CD44, IL6R, TREM2	ADAM12	ITGB1	ADAM15	ITGB1	ADAM17	ERBB4, IL6R, ITGB1
ADAM2	ITGB1, ITGB7	ADAM9	ITGB1	AGRN	ITGB1	AMH	ACVR1, AMHR2, BMPR1A, EGFR
ANG	EGFR	ANGPT1	ITGB1	ANXA1	ADRA2A, DYSF, EGFR, FPR1, FPR2, FPR3, GRM7, LXA4, MTNR1A	APOC3	TLR2
APOE	LRP5, TREM2	APP	CD74, FPR2	AREGB	EGFR	AREG	EGFR
ARF4	EGFR	ARTN	GFRA1, GFRA2, GFRA3, RET	B2M	KLRC1, KLRC2, KLRD1	BCAN	EGFR
BGN	TLR2	BMP10	BMPR1B, BMPR2	BMP15	BMPR1B, BMPR2	BMP1	BMPR1B, BMPR2
BMP2	ACVR1, BMPR1B, BMPR2	BMP3	BMPR1B, BMPR2	BMP4	BMPR1B, BMPR2	BMP5	BMPR1B, BMPR2
BMP6	ACVR1, BMPR1B, BMPR2	BMP7	ACVR1, BMPR1B, BMPR2	BMP8A	BMPR1B, BMPR2	BMP8B	BMPR1A, BMPR1B, BMPR2, PLAUR
BTC	EGFR, ERBB4	C4BPA	BMPR2	CALM1	EGFR	CALM2	EGFR
CALM3	EGFR	CAMP	EGFR, FPR2	CCN1	TLR2	CCN2	EGFR, ERBB4

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Oncogenes and tumor suppressor genes (TSGs) were collected from Cancer Gene Census (CGC), OncoKB, Network of Cancer Genes (NCG), TSGene, IntOGene and Volkan Okur and Wendy K. Chung, 2017. The following figures only displayed the expression of oncogenes and TSGs supported by three or more databases or other sources.