Life science and biomedical research have an absolute depency on data; little advance is made without the use of existing data or the generation of new data, and frequently researchers deploy a combination of these two. Biodata resources - the databases and services that allow scientists to access, share, curate, integrate and interpret biological data - exist as an ecosystem of more than 3,000 distinct but connected elements of a critical open data infrastructure in use continuously by scientists around the world. Unlike scientific infrastructures outside the life and biomedical sciences, though, these elements - the individual data resources - have emerged from the scientific community with no global coordination. While this brings advantages that are worthy, such as that users are closely connected to the design of data services, the lack of coordination brings a great fragility to individual data resources and a very real threat to their sustainability. The Global Biodata Coalition, a coalition of life science and biomedical research funding organisations came together to address issues of sustainability in the biodata resource infrastructure. An active programme of work includes exploration of the infrastructure landscape, selection processes for data resources with particularly broad global importance and expert discussions towards mechanisms that better support global cooperation between life science funding organisations. In the presentation I will outline the nature of biodata resources and the infrastructure that they make up, present the sustainability challenges and introduce the work of the GBC including its exploration of the global biodata resource landscape and Global Core Biodata Resource selection programme. Finally I will introduce the recently presented papers and ongoing consultation on open data strategies and sustainability of biodata resource.