Disease Description: Abnormal development and/or function of certain types of white globoid cells in the brain. Krabbe disease.
Inherit Mode: This is a rare disorder that is seen most often in the Cairn and West Highland white terriers, in which it is inherited as an autosomal recessive trait. It is also autosomal recessive in the miniature poodle, Irish setter and Australian kelpie. The mode of inheritance is unknown in other breeds.
Disease Symptom: Puppies affected with GCL are normal at birth but grow more slowly than their littermates, and begin to to show signs of incoordination by 3 to 6 months. You may see tremors, a stiff gait, weakness, poor balance (falling to one side, stumbling), changes in behaviour or attitude, and vision changes. The disease is rapidly progressive and is invariably fatal. Affected dogs generally die or are euthanized by about 12 months.
Disease Cause: -
Disease Diagnose: Your veterinarian will do a thorough neurologic exam on your dog. Diagnostic tests for other conditions that might cause your dog's signs will show no abnormalities. As the disease progresses, magnetic resonance imaging (if available) will show diffuse disease in the white matter. There is a DNAtest available through HealthGene that will identiify normal, carrier (heterozygous) and affected Cairn terriers and Westies. A DNA test is also available in some other breeds. See the Orthopedic Foundation of America's currently available tests for more information.
Treat Method: Unfortunately there is no treatment for this condition. Your veterinarian will help you decide when your dog's condition has deteriorated to the point where euthanasia is the best option.
Breeder Advice: Affected animals and their parents (who are carriers of the defective gene) should not be bred. There is a DNAtest available through HealthGene that will identiify normal, carrier (heterozygous) and affected Cairn terriers and Westies. A DNA test is also available in some other breeds. See the Orthopedic Foundation of America's currently available tests for more information.
Disease Description Source: Link
Disease Name | Other Name | Mode of inheritance | Link ID | Possible OMIM ID | Gene |
---|---|---|---|---|---|
Krabbe disease | globoid cell leukodystrophy | Autosomal Recessive | GALC |
iDog Breed Number | Breed Name | Personality | Height | Weight | Breed Source |
---|---|---|---|---|---|
CB23 | Bavarian Mountain Scent Hound | Loyal, Versatile, Reserved with Strangers | 17-20.5 inches | 37-66 pound | |
CB24 | English Beagle | Merry, friendly, and curious | 33 cm & under 33-38.1 cm | under 9.1 kg (5.9 inches & under), 9.1-13.6 kg (5.9-6.8 inches) | United Kingdom (England) |
CB25 | Bearded Collie | Bouncy, charismatic, friendly; smart, but also stubborn and independent | 53.3-55.9 cm (male), 50.8-53.3 cm (female) | 20.4-24.9 kg | United Kingdom (Scotland) |
CB40 | Bluetick Coonhound | Smart,Fearless | 55.9-68.6 cm (male), 53.3-63.5 cm (female) | 24.9-36.3 kg (male), 20.4-29.5 kg (female) | United States |
CB41 | Boerboel(South African Mastiff) | Smart, dominant, protective, confident; loving with family, especially kids | 61-68.6 cm (male), 55.9-63.5 cm (female) | 68-90.7 kg | South Africa |
CB60 | Cairn Terrier | Cheerful, alert, busy and independent-minded | 25.4 cm (male), 24.1 cm (female) | 6.4 kg (male), 5.9 kg (female) | United Kingdom (Scotland) |
CB61 | Canaan Dog | Alert, vigilant, territorial; docile with family, aloof with strangers | 50.8-61 cm (male), 48.3-58.4 cm (female) | 20.4-24.9 kg (male), 15.9-20.4 kg (female) | Middle East Lebanon - Israel |
CB84 | Dalmatian | Stable, Outgoing;Dignified but never shy | 48.3-61 cm | 20.4-31.8 kg | Croatia |
CB85 | Dandie Dinmont Terrier | Independent, proud, smart; affectionate at home, bold and tenacious in the field | 20.3-27.9 cm | 8.2-10.9 kg | United Kingdom (Scotland) |
CB131 | Irish Setter | Outgoing, sweet-natured, active, and trainable | 68.6 cm (male), 63.5 cm (female) | 31.8 kg (male), 27.2 kg (female) | Ireland |
CB188 | Poodle | Proud, active and very smart | 25.4 cm & under (toy), 25.4-38.1 cm (miniature), over 38.1 cm (standard) | 1.8-2.7 kg (toy), 4.5-6.8 kg (miniature), 27.2-31.8 kg (male standard), 18.1-22.7 kg (female standard) | Germany, France |
CB255 | West Highland White Terrier | Happy, smart, loyal, entertaining | 27.9 cm (male). 25.4 cm, female | 6.8-9.1 kg | United Kingdom (Scotland) |
CB256 | English Whippet | Calm, affectionate, and playful | 48.3-55.9 cm (male), 45.7-53.3 cm (female) | 11.3-18.1 kg | England |
CB266 | Australian Kelpie | Alert, eager and highly intelligent, with an inexhaustible energy, loyalty and devotion to duty. | 43-51 cm | Australia | |
CB268 | Miniature Poodle | Intelligent, Eager-to-please , Charming companion | 25-38 cm | 4.5-6.8kg | France&Germany |
CB270 | Toy Poodle | Intelligent, eager to please, quick to learn and an affectionate, loyal pet. | under 25 cm |
2020 |
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2020 |
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2016 |
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2016 |
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2015 |
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2010 |
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2010 |
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2008 |
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2008 |
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