Disease Description: A condition where the cerebellum, a part of the brain, is poorly formed (too small or absent) and doesn't function properly or at all.
Inherit Mode: Autosomal recessive. This disorder is rare. There are sporadic reports of this disorder in breeds other than those listed below.
Disease Symptom: The cerebellum is the part of the brain that regulates the control and coordination of voluntary movement. The clinical signs of cerebellar dysfunction in affected puppies range from mild to severe, and may include poor balance, a wide-based stance (feet planted far apart), stiff or high-stepping gait, apparent lack of awareness of where the feet are (standing or walking with a foot knuckled over), and head or body tremors. Affected pups have normal mental alertness. In this condition, in contrast to cerebellar abiotrophy, signs of cerebellar dysfunction are evident at birth or by 2 weeks thereafter, and do not get worse as the pup ages. Other than the abnormalities in balance and coordination, the animal's general health is unaffected.
Disease Cause: -
Disease Diagnose: The clinical signs (relating to uncoordinated movement and lack of balance) are evident as soon as the pups are walking and are suggestive of a cerebellar disorder. Your veterinarian will do tests to rule out other conditions that can cause similar signs.
Treat Method: There is no treatment for this condition. Affected dogs will not get any worse (or better) and, especially where the signs are mild, may be able to lead a relatively normal life, particularly if owners can adjust their expectations to the dog's limitations.
Breeder Advice: Affected dogs, their parents and their siblings should not be used for breeding.
Disease Description Source: Link
Disease Name | Other Name | Mode of inheritance | Link ID | Possible OMIM ID | Gene |
---|---|---|---|---|---|
Cerebellar hypoplasia | - | Autosomal Recessive | - | ||
Granule cell type cerebellar hypoplasia | - | - | - | - | |
Lissencephaly and cerebellar hypoplasia | - | - | - | ||
Cerebellar hypoplasia, VLDLR-associated | Dandy-Walker-like malformation | Autosomal Recessive | VLDLR |
iDog Breed Number | Breed Name | Personality | Height | Weight | Breed Source |
---|---|---|---|---|---|
CB3 | Airedale Terrier | Clever, confident, proud; friendly but courageous | 58.4 cm | 22.7-31.8 kg | United Kingdom (England) |
CB61 | Canaan Dog | Alert, vigilant, territorial; docile with family, aloof with strangers | 50.8-61 cm (male), 48.3-58.4 cm (female) | 20.4-24.9 kg (male), 15.9-20.4 kg (female) | Middle East Lebanon - Israel |
CB75 | Chow Chow | Serious-minded, dignified, bright, and aloof | 43.2-50.8 cm | 20.4-31.8 kg | China |
CB76 | Cirneco dell'Etna | Affectionate, Friendly, Independent | 18-19.5 inches (male), 16.5-18 inches (female) | 22-26 pounds (male), 17-22 pounds (female) | Italy |
CB102 | Field Spaniel | Sweet, sensitive, fun-loving, and smart; a real people-pleaser | 45.7 cm (male), 43.2 cm (female) | 15.9-22.7 kg | United Kingdom (England) |
CB120 | Great Pyrenees | Calm, patient, smart; strong-willed yet affectionate | 68.6-81.3 cm (male), 63.5-73.7 cm (female) | 45.4 kg & up (male), 38.6 kg & up (female) | France, Spain |
CB131 | Irish Setter | Outgoing, sweet-natured, active, and trainable | 68.6 cm (male), 63.5 cm (female) | 31.8 kg (male), 27.2 kg (female) | Ireland |
2016 |
Fraser,A.R.,leChevoir,M.A.,Long,S.N.: :
Lissencephaly in an adult Australian Kelpie. Aust Vet J 94:107-10, 2016. Pubmed reference: 27021891 . DOI: 10.1111/avj.12423 . |
2015 |
Bernardino,F.,Rentmeister,K.,Schmidt,M.J.,Bruehschwein,A.,Matiasek,K.,Matiasek,L.A.,Lauda,A.,Schoon,H.A.,Fischer,A.: :
Inferior cerebellar hypoplasia resembling a dandy-walker-like malformation in purebred eurasier dogs with familial non-progressive ataxia: a retrospective and prospective clinical cohort study. PLoS One 10:e0117670, 2015. Pubmed reference: 25668516 . DOI: 10.1371/journal.pone.0117670 . |
2015 |
Gerber,M.,Fischer,A.,Jagannathan,V.,Drögemüller,M.,Drögemüller,C.,Schmidt,M.J.,Bernardino,F.,Manz,E.,Matiasek,K.,Rentmeister,K.,Leeb,T.: :
A deletion in the VLDLR gene in Eurasier dogs with cerebellar hypoplasia resembling a Dandy-Walker-like malformation (DWLM). PLoS One 10:e0108917, 2015. Pubmed reference: 25668033 . DOI: 10.1371/journal.pone.0108917 . |
2011 |
Lee,K.I.,Lim,C.Y.,Kang,B.T.,Park,H.M.: :
Clinical and MRI findings of lissencephaly in a mixed breed dog. J Vet Med Sci 73:1385-8, 2011. Pubmed reference: 21685716 . |
2010 |
Jones B, Shiel R. :
Neurologic disorders. Shaer M, ed. Clinical Medicine of the Dog and Cat. London, UK:Manson, 2010: 644. |
2003 |
Schatzberg,S.J.,Haley,N.J.,Barr,S.C.,Parrish,C.,Steingold,S.,Summers,B.A.,deLahunta,A.,Kornegay,J.N.,Sharp,N.J.: :
Polymerase chain reaction (PCR) amplification of parvoviral DNA from the brains of dogs and cats with cerebellar hypoplasia.[comment] Journal of Veterinary Internal Medicine 17:538-44, 2003. Pubmed reference: 12892305 . |
2002 |
Saito,M.,Sharp,N.J.,Kortz,G.D.,deLahunta,A.,Leventer,R.J.,Tokuriki,M.,Thrall,D.E.: :
Magnetic resonance imaging features of lissencephaly in 2 Lhasa Apsos. Vet Radiol Ultrasound 43:331-7, 2002. Pubmed reference: 12174995 . |
1996 |
Coates, J.R. :
Weeble, wobble, roly, poly: a study of cerebellar disease. ACVIM-Proceedings of the 14th Annual Vet. Med. Forum. pp 684-687. |
1993 |
Tago,Y.,Katsuta,O.,Tsuchitani,M.: :
Granule Cell Type Cerebellar Hypoplasia in a Beagle Dog Laboratory Animals 27:151-155, 1993. Pubmed reference: 8501896 . |
1979 |
Knecht,C.D.,Lamar,C.H.,Schaible,R.,Pflum,K.: :
Cerebellar hypoplasia in Chow Chows. Journal of the American Animal Hospital Association 15:51-53, 1979. |
1976 |
Greene,C.E.,Vandevelde,M.,Braund,K.: :
Lissencephaly in two Lhasa Apso dogs. J Am Vet Med Assoc 169:405-10, 1976. Pubmed reference: 956022 . |
1976 |
Zaki,F.A.: :
Lissencephaly in Lhasa Apso dogs. J Am Vet Med Assoc 169:1165, 1168, 1976. Pubmed reference: 1033927 . |