LncBook 2.0 Integrating human long non-coding RNAs with multi-omics annotations

LncBook accommodates a high-quality collection of human lncRNA genes and incorporates their abundant annotations at different omics levels, thereby enabling users to decipher functional signatures of lncRNAs in human diseases and different biological contexts.

Multi-omics Annotations

Conservation Features across 40 Vertebrates
959,138 Disease/trait-associated Variants
DNA Methylation Profiles in 16 Diseases

Expression Capacities across 9 Biological Contexts

34,012 Small Proteins
146,092,274 LncRNA-miRNA Interactions;
772,745 LncRNA-Protein Interactions

Tools

Conversion across 14 Resources
Coding Potential Prediction
Search by Sequence
Genomic Location Annotation

Publications:

LncBook 2.0: integrating human long non-coding RNAs with multi-omics annotations. Nucleic Acids Res 2022 [PMID=36330950], [OLB-PM=36330950]
LncBook: a curated knowledgebase of human long non-coding RNAs. Nucleic Acids Res 2019 [PMID=30329098]

News & Updates:

06/13/2022 - LncBook 2.0 was released

03/10/2020 - version 1.9

  • LncRNA transcripts were integrated from 8 resources, including LncBook v1.2, GENCODE, RefLnc, NONCODE, CHESS, FANTOM, BIGTranscriptome and MiTranscriptome and curated by a series of strict processes.

11/19/2019 - version 1.2

  • Genomic locations, exactly beginning sites, for the single-exon transcripts derived from NONCODE database were corrected, and the related genes’ locations were also modified.

08/29/2019 - version 1.1

  • To facilitate overall investigation of various RNAs, a comprehensive RNA reference dataset was created, including lncRNA annotations from LncBook and other RNAs’annotations derived from GENCODE v31.
  • Both hg19 (GRCh37) and GRCh38 versions were provided, which are freely available in the download page.

07/02/2019 - version 1.1

  • 1196 redundant lncRNA transcripts removed
  • Genomic annotations of 1046 lncRNA transcripts updated
  • Erroneous gene locations corrected
  • TS lncRNAs of specific tissues can be accessed in expression page
  • Data imported to RNAcentral release 12

06/20/2019 - version 1.0