An Approach for Differential Diagnosis of Breast tumours by ctDNA Methylation Sequencing
| Title | An Approach for Differential Diagnosis of Breast tumours by ctDNA Methylation Sequencing |
|---|---|
| Description | We developed a 103-marker methylation model using targeted methylation sequencing to differentiate between benign and malignant breast tumors, and we validated its diagnostic performance in a validation set and two independent test sets. We provided patient imaging, molecular typing, and prognostic information to compare the diagnostic performance of the 103-marker methylation model with breast ultrasound, mammography, and different molecular subtypes. Additionally, we utilized the cancer score from the methylation model to predict the prognosis of patients with breast cancer |
| Organism | Homo sapiens |
| Data Type | Condition-specific Biomarkers |
| Data Accessibility | Controlled-access |
| BioProject | PRJCA016104 |
| Release Date | 2024-04-25 |
| Submitter | Xianyu Zhang (zhangxianyu@ems.hrbmu.edu.cn) |
| Organization | Harbin Medical University Cancer Hospital |
| Submission Date | 2024-04-23 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX006303-01 | Basic information of breast mass patients who provided tissue samples and plasma samples for our study | 501 | Condition-specific Biomarkers | 124.3 KB | xlsx | 0 | Controlled |
| OMIX006303-02 | Functional enrichment of selected methylation markers | 1 | Condition-specific Biomarkers | 17.5 KB | xlsx | 0 | Controlled |
| OMIX006303-03 | Genes annotation of selected methylation markers | 1 | Condition-specific Biomarkers | 90.2 KB | xlsx | 0 | Controlled |