We present the problems, methodology and statistics of a large scale clinical trial concerning biochemical events and compatibility of carbohydrate infusions. The presented work serves as introduction to understand the following publications from this study. More specifically we show the results of 48-hour infusion of the following solutions: 1. Glucose, 2. Glucose/Fructose, 3. Glucose/Sorbitol, 4. Glucose/Xylitol, 5. Glucose/Fructose/Xylitol. Each of the infusion series was applicated to patients with liver cirrhosis; diabetes mellitus, and a metabolically healthy control group.