The paper presents a computational study dealing with the patient's response to the change in dialysis time schedule from 7 hours twice a week to 4 hours thrice a week. The problem is treated in a purely mathematical way, based on a 3-pool model of the patient-artificial kidney system (one compartment represents patient's intracellular and extracellular volume, respectively, one compartment is reserved for description of the artificial kidney itself). The calculation was performed for two extreme values of intercompartmental permeability coefficient K and for two different values of dialysance of the dialyzer used. The results obtained are presented in form of graphs and tables and are in excellent accordance with the clinical results reported recently by Válek and co-workers.
