Sex-related differences of hepatic microsomal mixed function oxidase system and antibody production in broilers implanted with corticosterone and/or fed ascorbic acid.

K Takahashi, Y Akiba, M Horiguchi
Author Information
  1. K Takahashi: Department of Animal Science, Faculty of Agriculture, Tohoku University, Sendai-Shi, Japan.

Abstract

1. Most of the components of the mixed function oxidase (MFO) in hepatic microsomes were reduced by corticosterone implants, and the degree of the reduction in females and at an older age was greater than those in males and at a younger age. 2. Ascorbic acid (AA) prevented the reduction in the MFO caused by corticosterone implants. 3. The activities of aniline hydroxylase and aminopyrine N-demethylase were enhanced by corticosterone implants regardless of AA supplementation. 4. The activity of NADPH-cytochrome c reductase in male broiler was greater than that in females under normal conditions. 5. Corticosterone implants and dietary AA had less influence on the antibody production, especially to T-cell dependent antigen.

MeSH Term

Aging
Animals
Antibody Formation
Ascorbic Acid
Chickens
Corticosterone
Diet
Drug Implants
Female
Male
Microsomes, Liver
Mixed Function Oxygenases
Sex Characteristics

Chemicals

Drug Implants
Mixed Function Oxygenases
Ascorbic Acid
Corticosterone

Word Cloud

Created with Highcharts 10.0.0corticosteroneimplantsAAmixedfunctionoxidaseMFOhepaticreductionfemalesagegreateracidantibodyproduction1componentsmicrosomesreduceddegreeoldermalesyounger2Ascorbicpreventedcaused3activitiesanilinehydroxylaseaminopyrineN-demethylaseenhancedregardlesssupplementation4activityNADPH-cytochromecreductasemalebroilernormalconditions5CorticosteronedietarylessinfluenceespeciallyT-celldependentantigenSex-relateddifferencesmicrosomalsystembroilersimplantedand/orfedascorbic

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