Intensive use of various emitters of radiofrequency electromagnetic fields is a potential health hazard both for workers and general population. Thus, improved hygienic regulation and control of nonionizing electromagnetic radiation becomes very important for prophylactics. Hygienic regulation of radiofrequency electromagnetic fields is based on elimination of their influence on human health. Incomplete knowledge of biologic mechanisms underlying influence of low-intensity radiofrequency electromagnetic fields is a serious obstacle to further improvement of hygienic regulation. Special attention should be paid on clinical, physiologic and epidemiologic research aimed to study long-term effects and influence of the stated fields on general morbidity.