Combinatorial approach to development of peptides that recognize DNA tetraloops.

N Sugimoto, S Okabe, M Yoneyama

Author Information

N Sugimoto: Department of Chemistry, Faculty of Science, Konan University, Kobe, Japan.

PMID: 10780438 DOI: 10.1093/nass/42.1.179

We report recognition system for DNA tetraloops (dA1G2G3C4T5T6C7G8G9C10C11T12 (core) and dAGGCTTCGGCCT (AP2); X = abasic nucleotide) by peptides selected with combinatorial chemistry. As a result, peptides with Thr/Glu/His and Gln/Asp were obtained in binding of DNA core and AP2, respectively.

Amino Acids

Base Pairing

Base Sequence

Binding Sites

Combinatorial Chemistry Techniques

DNA

Nucleic Acid Conformation

Oligodeoxyribonucleotides

Peptide Library

Peptides

Thermodynamics

Amino Acids

Oligodeoxyribonucleotides

Peptide Library

Peptides

DNA

Journal Article Research Support, Non-U.S. Gov't

No available data.

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